Terlipressin Acetate rau Esophageal Variceal Bleeding
Product Detail
| Lub npe | N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin |
| CAS nr | 14636-12-5 |
| Cov mis mos molecular | C52H74N16O15S2 |
| Molecular hnyav | 1227.37 Nws |
| EINECS Number | 238-680-8 : kuv |
| Boiling point | 1824.0 ± 65.0 ° C (Predicted) |
| Qhov ntom | 1.46 ± 0.1 g / cm3 (Kev kwv yees) |
| Cia tej yam kev mob | Khaws nyob rau hauv qhov chaw tsaus, Inert cua, Khaws rau hauv lub freezer, hauv qab -15 ° C. |
| Acidity coefficient | (pKa) 9.90 ± 0.15 (Predicted) |
Synonyms
[N-α-Triglycyl-8-lysine]-vasopressin; 130: PN: WO2010033207SEQID: 171claiMedprotein;1-Triglycyl-8-lysineVasopressin;Nα-Glycyl-glycyl-glycyl-[8-lysine]-vasopressin;Nα-Glycyl-glycyl-glycyl-lysine-vasopressin;Nα-Glycylglycylglycyl-vasopressin;Nα-Gly-Gly-Gly-8-Lys-vasopressin;Terlipressin, Terlipressine, Terlipressina, Terlipressinum.
Kev piav qhia
Terlipressin, nws lub npe tshuaj yog triglycyllysine vasopressin, yog ib qho tshiab hluavtaws vasopressin npaj.Nws yog ib hom prodrug, uas yog inactive los ntawm nws tus kheej.Nws yog ua los ntawm aminopeptidase nyob rau hauv vivo kom maj mam "tso" cov nquag lysine vasopressin tom qab tshem tawm peb glycyl residues ntawm nws N-terminus.Yog li ntawd, terlipressin ua raws li lub reservoir uas tso tawm lysine vasopressin ntawm tus nqi tsis tu ncua.
Cov nyhuv pharmacological ntawm terlipressin yog cog lus splanchnic vascular du leeg thiab txo cov ntshav splanchnic (xws li txo cov ntshav ntws hauv mesentery, spleen, uterus, thiab lwm yam), yog li txo cov ntshav ntws thiab portal siab.Ntawm qhov tod tes, nws tuaj yeem txo cov ntshav plasma Cov nyhuv ntawm renin concentration, yog li ua rau lub raum cov ntshav khiav, txhim kho lub raum ua haujlwm thiab nce zis tso zis rau cov neeg mob hepatorenal syndrome.Terlipressin tam sim no tsuas yog cov tshuaj uas tuaj yeem txhim kho txoj sia nyob ntawm cov neeg mob uas muaj variceal hemorrhage esophageal.Nws yog tsuas yog siv nyob rau hauv kev kho mob ntawm variceal hemorrhage.Tsis tas li ntawd, terlipressin kuj tau siv tau zoo hauv daim siab thiab lub raum.Feem ntau, nws zoo li yuav ua lub luag haujlwm muaj txiaj ntsig hauv kev sib koom ua ke refractory shock thiab cardiopulmonary resuscitation.Piv nrog vasopressin, nws muaj cov nyhuv ntev, tsis ua rau muaj teeb meem txaus ntshai, suav nrog fibrinolysis thiab teeb meem loj hauv cov hlab plawv, thiab siv tau yooj yim (kev txhaj tshuaj intravenous), uas yog qhov tsim nyog rau kev kho mob hnyav dua.Kev cawm thiab kho cov neeg mob hnyav.
