Lub npe | Eptifibatide |
CAS nr | 188627-80-7 |
Cov mis mos molecular | C35H49N11O9S2 |
Molecular hnyav | 831.96 ib |
EINECS Number | 641-366-7 |
Qhov ntom | 1.60 ± 0.1 g / cm3 (Kev kwv yees) |
Cia tej yam kev mob | Muab ntim rau hauv qhuav, khaws cia hauv lub tub yees, qis dua -15 ° C |
Eptifibatideacetatesalt; Eptifibatide, MPA-HAR-Gly-Asp-Trp-Pro-Cys-NH2, MPAHARGDWPC-NH2,> 99%; MAP-LYS-GLY-ASP-TRP-PRO-CYS-NH2; INTEGRELIN; Eptifibatide; N6- (Aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl-L-lysylglycyl-La-aspartyl-L-tryptophyl-L-prolyl-L-cysteamide; MPA-HAR-GLY-ASP-TRP-PRO-CYS-NH2 (DISULFIDEBRIDGE, MPA1-CYS6).
Etifibatide (integrilin) yog ib qho tshiab polypeptide platelet glycoprotein IIb / IIIa receptor antagonist, uas inhibits platelet aggregation thiab thrombosis los ntawm inhibiting txoj kev kawg ntawm platelet aggregation.Piv nrog rau monoclonal antibody abciximab, eptifibatide muaj zog dua, muaj kev taw qhia ntau dua thiab tshwj xeeb khi rau GPIIb / IIIa vim tias muaj ib qho kev tiv thaiv amino acid hloov pauv-lysine los hloov arginine.Yog li ntawd, nws yuav tsum muaj kev kho mob zoo hauv kev kho mob ntawm tus mob coronary syndrome.Platelet glycoprotein IIb/IIIa receptor antagonist tshuaj tau tsim ntau heev, thiab tam sim no muaj 3 hom kev npaj uas tuaj yeem siv rau hauv kev kho mob thoob ntiaj teb, abciximab, eptifibatide thiab tirofiban.).Muaj kev paub me ntsis hauv kev siv cov platelet glycoprotein GPIIb / IIIa receptor antagonists hauv Suav teb, thiab cov tshuaj muaj kuj tseem txwv.Tsuas yog ib qho tshuaj, tirofiban hydrochloride, muaj nyob hauv khw.Yog li ntawd, ib qho tshiab platelet glycoprotein IIb tau tsim./IIIa receptor antagonists yog qhov tseem ceeb.Hauv tsev eptifibatide yog ib qho khoom siv coj los ua los ntawm Chengdu Sino Biological Products Co., Ltd.
Kev faib tawm ntawm Antiplatelet Aggregation Tshuaj
Cov tshuaj Antiplatelet aggregation tuaj yeem faib ua peb pawg: 1. Cyclooxygenase-1 (COX-1) inhibitors, xws li tshuaj aspirin.2. inhibit platelet aggregation induced los ntawm adenosine diphosphate (ADP), xws li clopidogrel, prasugrel, cangrelor, ticagrelor, thiab lwm yam. 3. Platelet glycoprotein Ⅱb/Ⅲa receptor antagonists, xws li abciximab, tifibanide, ntxiv rau, muaj. prostaglandin EP3 receptor inhibitors, tshiab tshuaj synthesized Cheebtsam thiab zoo extracts los ntawm tsoos suav tshuaj.