Leuprorelin Acetate tswj kev zais cia ntawm Gonadal Hormones
Product Detail
| Lub npe | Leuprorelin |
| CAS nr | 53714-56-0 |
| Cov mis mos molecular | C59H84N16O12 |
| Molecular hnyav | 1 209.4 |
| EINECS Number | 633-395-9 |
| Kev sib hloov tshwj xeeb | D25 -31.7 ° (c = 1 hauv 1% acetic acid) |
| Qhov ntom | 1.44 ± 0.1 g / cm3 (Kev kwv yees) |
| Kev cia khoom | -15 ° C |
| Daim ntawv | Tsis zoo |
| Acidity coefficient | (pKa) 9.82 ± 0.15 (Predicted) |
| Dej solubility | Soluble hauv dej ntawm 1mg / ml |
Synonyms
LH-RHLEUPROLIDE;LEUPROLIDE;LEUPROLIDE(HUMAN);LEUPRORELIN;[DES-GLY10,D-LEU6,PRO-NHET9]-LUTEINIZINGHORMONE-RELEASINGHORMONEHUMAN;(DES-GLY10,D-LEU6,PRO-NHET-9) DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINGhormone-Tshem tawm;[DES-GLY10,D-LEU6,PRO-NHET9]-LH-RH(Human)
Pharmacological nyhuv
Leuprolide, goserelin, triprelin, thiab nafarelin yog ntau yam tshuaj uas feem ntau siv hauv kev kho mob kom tshem tawm zes qe menyuam rau kev kho mob cancer mis premenopausal thiab mob qog noj ntshav prostate.(hu ua GnRH-ib tshuaj), GnRH-ib cov tshuaj zoo sib xws hauv cov qauv rau GnRH thiab sib tw nrog pituitary GnRH receptors.Ntawd yog, gonadotropin secreted los ntawm pituitary txo qis, uas ua rau txo qis hauv kev sib deev hormone secreted los ntawm zes qe menyuam.
Leuprolide yog ib qho gonadotropin-tso hormone (GnRH) analog, peptide muaj li ntawm 9 amino acids.Cov khoom no tuaj yeem cuam tshuam kev ua haujlwm ntawm pituitary-gonadal system, tiv thaiv proteolytic enzymes thiab affinity rau pituitary GnRH receptor muaj zog dua GnRH, thiab kev ua haujlwm ntawm kev txhawb kev tso tawm ntawm luteinizing hormone (LH) yog li 20 npaug ntawm cov khoom no. ntawm GnRH.Nws kuj muaj zog inhibitory nyhuv ntawm pituitary-gonad muaj nuj nqi tshaj GnRH.Hauv thawj theem ntawm kev kho mob, follicle stimulating hormone (FSH), LH, estrogen lossis androgen tuaj yeem nce ib ntus, thiab tom qab ntawd, vim qhov txo qis ntawm cov qog pituitary, qhov tso tawm ntawm FSH, LH thiab estrogen lossis androgen yog inhibited, ua rau muaj kev vam meej ntawm kev sib deev cov tshuaj hormones.Cov kab mob sib deev (xws li mob qog noj ntshav prostate, endometriosis, thiab lwm yam) muaj kev kho mob.
Tam sim no, acetate ntsev ntawm leuprolide feem ntau yog siv nyob rau hauv kev kho mob, vim hais tias kev ua tau zoo ntawm leuprolide acetate yog ruaj khov nyob rau hauv chav tsev kub.Cov kua yuav tsum tau muab pov tseg.Nws tuaj yeem siv rau kev kho mob castration ntawm endometriosis thiab uterine fibroids, central precocious puberty, premenopausal mis cancer thiab prostate cancer, thiab kuj rau functional uterine los ntshav uas yog contraindicated los yog ineffective rau cov pa tshuaj hormonal kho.Nws kuj tseem siv tau los ua cov tshuaj premedication ua ntej endometrial resection, uas tuaj yeem sib npaug ntawm cov endometrium, txo edema, thiab txo qhov nyuaj ntawm kev phais.
