Lub npe | Atosiban |
CAS nr | 90779-69-4 |
Cov mis mos molecular | C43H67N11O12S2 |
Molecular hnyav | 994.19 ib |
EINECS Number | 806-815-5 |
Boiling point | 1469.0 ± 65.0 ° C (Predicted) |
Qhov ntom | 1.254 ± 0.06 g / cm3 (Kev kwv yees) |
Cia tej yam kev mob | -20 ° C |
Solubility | H2O: 100 mg/ml |
Atosiban acetate yog disulfide-bonded cyclic polypeptide uas muaj 9 amino acids.Nws yog ib qho kev hloov pauv oxytocin molecule ntawm txoj haujlwm 1, 2, 4 thiab 8. N-terminus ntawm peptide yog 3-mercaptopropionic acid (thiol thiab sulfhydryl pawg ntawm [Cys]6 tsim ib daim ntawv cog lus disulfide), C-terminal yog Nyob rau hauv daim ntawv ntawm ib tug amide, qhov thib ob amino acid nyob rau hauv lub N-terminal yog ib tug ethylated hloov [D-Tyr(Et)]2, thiab atosiban acetate yog siv nyob rau hauv cov tshuaj raws li vinegar Nws muaj nyob rau hauv daim ntawv ntawm ib tug acid ntsev, feem ntau. Lub npe hu ua atosiban acetate.
Atosiban yog ib qho oxytocin thiab vasopressin V1A ua ke receptor antagonist, oxytocin receptor yog cov qauv zoo ib yam li vasopressin V1A receptor.Thaum cov oxytocin receptor raug thaiv, oxytocin tseem tuaj yeem ua los ntawm V1A receptor, yog li nws yog qhov tsim nyog los thaiv cov saum toj no ob txoj kev receptor tib lub sijhawm, thiab ib qho kev tawm tsam ntawm ib tus receptor tuaj yeem cuam tshuam uterine contraction.Qhov no kuj yog ib qho ntawm cov laj thawj tseem ceeb vim li cas β-receptor agonists, calcium channel blockers thiab prostaglandin synthase inhibitors tsis tuaj yeem cuam tshuam uterine contractions.
Atosiban yog ib qho kev sib xyaw receptor antagonist ntawm oxytocin thiab vasopressin V1A, nws cov qauv tshuaj zoo ib yam li ob, thiab nws muaj kev sib raug zoo rau cov receptors, thiab sib tw nrog oxytocin thiab vasopressin V1A receptors, yog li thaiv txoj kev ua ntawm oxytocin thiab vasopressin thiab txo. uterine contractions.