Ganirelix Acetate Peptide API

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Lub npe: Ganirelix Acetate

CAS Nr .: 123246-29-7

Cov mis mos molecular: C80H113ClN18O13

Molecular Luj: 1570.34

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Product Detail

Khoom cim npe

Product Detail

Lub npe	Ganirelix Acetate
CAS nr	123246-29-7
Cov mis mos molecular	C80H113ClN18O13
Molecular hnyav	1570.34 Nws

Synonyms

Ac-DNal-DCpa-DPal-Ser-Tyr-DHar(Et2)-Leu-Har(Et2)-Pro-DAla -NH2;Ganirelixum;ganirelix Acetate;GANIRELIX;Ganirelix Acetate USP/EP/

Kev piav qhia

Ganirelix yog ib qho hluavtaws decapeptide compound, thiab nws cov ntsev acetate, Ganirelix acetate yog gonadotropin-tso cov tshuaj hormones (GnRH) receptor antagonist.Cov amino acid sequence yog: Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-Tyr-D-HomoArg(9,10-Et2)-Leu-L-HomoArg(9,10-Et2)-Pro- D-Ala-NH2.Feem ntau hauv kev kho mob, nws yog siv rau cov poj niam uas tau txais kev pabcuam kev tsim cov cuab yeej siv tshuaj tiv thaiv zes qe menyuam txhawm rau tiv thaiv ntxov ntxov luteinizing hormone peaks thiab kho cov kab mob fertility vim qhov no.Cov tshuaj muaj cov yam ntxwv ntawm qhov tsis zoo tshwm sim tsawg, kev xeeb tub siab thiab lub sijhawm kho luv luv, thiab muaj qhov pom tseeb zoo piv nrog cov tshuaj zoo sib xws hauv kev kho mob.

Pharmacological Action

Lub pulsatile tso tawm ntawm gonadotropin-tso cov tshuaj hormones (GnRH) nkoos lub synthesis thiab secretion ntawm LH thiab FSH.Qhov zaus ntawm LH pulses nyob rau hauv nruab nrab thiab lig follicular theem yog kwv yees li 1 ib teev.Cov pulses no tau tshwm sim nyob rau hauv ib ntus nce hauv cov ntshav LH.Thaum lub sij hawm ib nrab ntawm kev coj khaub ncaws, qhov tso tawm loj ntawm GnRH ua rau muaj kev nce siab ntawm LH.Lub midmenstrual LH surge tuaj yeem ua rau ntau qhov kev xav ntawm lub cev, suav nrog: ovulation, oocyte meiotic resumption, thiab corpus luteum tsim.Kev tsim ntawm corpus luteum ua rau cov ntshav cov ntshav nce siab, thaum qib estradiol poob.Ganirelix acetate yog GnRH antagonist uas sib tw thaiv GnRH receptors ntawm pituitary gonadotrophs thiab cov kev hloov pauv tom ntej.Nws ua kom nrawm, thim rov qab inhibition ntawm gonadotropin secretion.Cov nyhuv inhibitory ntawm ganirelix acetate ntawm pituitary LH secretion muaj zog dua li ntawm FSH.Ganirelix acetate ua tsis tau tejyam rau induce thawj tso tawm ntawm endogenous gonadotropins, raws li antagonism.Kev ua kom tiav ntawm pituitary LH thiab FSH qib tau tshwm sim hauv 48 teev tom qab txiav tawm ganirelix acetate.

Yav dhau los: Cetrorelix Acetate los tiv thaiv ovulation ntxov ntxov 120287-85-6

Tom ntej: Linaclotide rau Gastrointestinal Disorders 851199-59-2

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