Linaclotide rau Gastrointestinal Disorders 851199-59-2
Product Detail
| Lub npe | Linaclotide |
| CAS nr | 851199-59-2 |
| Cov mis mos molecular | C59H79N15O21S6 |
| Molecular hnyav | 1526.74 ib |
Synonyms
Linacllotide; Linaclotide; Linaelotide Acetate; Linaelotide; CY-14; Liclotide; Argpessin; L-Tyrosine, L-cysteineyl-L-cysteyl-L-α-glutamyl-L-tyrosyl-L-cysteineyl-L-cysteineyl-L-asparaginyl- L-prolyl-L-alanyl-L-cysteineyl-L-threonylglycyl-L-cysteyl-, cyclic (1 → 6), (2 → 10), (5 → 13) - tris (disulfide)
Kev piav qhia
Linaclotide, ib tug hluavtaws peptide qauv uas muaj 14 amino acids, muaj feem xyuam rau endogenous guanosine peptide tsev neeg thiab tsuas yog FDA-pom zoo GC-C (guanylate) Cyclase-C) agonist tshuaj rau kev kho mob ntawm chim siab plob tsis so tswj syndrome nrog cem quav (IBS- C) thiab chronic idiopathic constipation (CIC) hauv cov laus.
Chemical Properties
Linaclotide yog cov hmoov dawb mus rau dawb amorphous;me ntsis soluble hauv dej thiab aqueous sodium chloride tov (0.9%).
Nws ua haujlwm li cas
Linaclotide yog guanylate cyclase-C receptor agonist (GCCA) nrog ob qho tib si visceral analgesic thiab endocrine kev ua.Ob leeg linaclotide thiab nws cov nquag metabolite tuaj yeem khi rau guanylate cyclase-C (GC-C) receptor nyob rau ntawm lub luminal nto ntawm lub plab hnyuv epithelium.Hauv cov qauv tsiaj, linaclotide txo qhov mob visceral thiab ua rau lub plab zom mov nce ntxiv los ntawm kev ua kom GC-C, thiab hauv tib neeg, cov tshuaj kuj ua rau cov kab mob colonic nce ntxiv.Qhov tshwm sim ntawm GC-C ua kom muaj zog ntxiv hauv cov cellular thiab extracellular cGMP (cyclic guanosine monophosphate) concentrations.Extracellular cGMP tuaj yeem txo qhov kev ua haujlwm ntawm qhov mob paj hlwb thiab txo qhov mob visceral hauv cov qauv tsiaj.Intracellular cGMP tuaj yeem ua rau kom muaj cov tshuaj chloride thiab bicarbonate nyob rau hauv txoj hnyuv me los ntawm kev ua kom CFTR (cystic fibrosis transmembrane conductance regulator), uas nws thiaj li ua rau kom cov kua hauv plab hnyuv loj zuj zus ntxiv thiab qhov ceev ntawm txoj hnyuv me.
FAQ
Koj puas tau lees tias muaj kev nyab xeeb thiab nyab xeeb ntawm cov khoom xa tuaj?
Yog lawm, peb ib txwm siv cov khoom ntim zoo export.Peb kuj tseem siv cov ntim khoom tshwj xeeb rau cov khoom txaus ntshai thiab siv tau cov neeg xa khoom txias cia rau cov khoom kub.Cov khoom ntim tshwj xeeb thiab cov khoom ntim uas tsis yog qauv yuav raug them nqi ntxiv.
Yuav ua li cas txog tus nqi shipping?
Tus nqi shipping nyob ntawm txoj kev koj xaiv kom tau cov khoom.Kev nthuav qhia feem ntau yog qhov nrawm tshaj plaws tab sis kuj tseem kim tshaj plaws.Los ntawm hiav txwv freight yog qhov kev daws teeb meem zoo tshaj plaws rau cov nyiaj loj.Raws nraim cov nqi thauj khoom peb tuaj yeem muab rau koj yog tias peb paub cov ntsiab lus ntawm tus nqi, qhov hnyav thiab txoj kev.Thov hu rau peb kom paub ntxiv.
