Semaglutide rau Hom 2 Ntshav Qab Zib
Product Detail
| Lub npe | Semaglutide |
| CAS nr | 910463-68-2 |
| Cov mis mos molecular | C187H291N45O59 |
| Molecular hnyav | 4113.57754 ib |
| EINECS Number | 203-405-2 : kuv |
Synonyms
Sermaglutide;Semaglutide fandachem;Semaglutide impurity;Sermaglutide USP / EP;semaglutide;Sermaglutide CAS 910463 68 2;Ozempic,
Kev piav qhia
Semaglutide yog ib tiam tshiab ntawm GLP-1 (glucagon-zoo li peptide-1) analogs, thiab semaglutide yog ib daim ntawv siv ntev ntev uas tsim los ntawm cov qauv ntawm liraglutide, uas muaj cov txiaj ntsig zoo hauv kev kho mob ntshav qab zib hom 2.Novo Nordisk tau ua tiav 6 Phase IIIa kev tshawb fawb ntawm kev txhaj tshuaj semaglutide, thiab xa daim ntawv thov sau npe tshuaj tshiab rau kev txhaj tshuaj semaglutide txhua lub lis piam mus rau US Food and Drug Administration (FDA) thaum Lub Kaum Ob Hlis 5, 2016. Daim Ntawv Thov Kev Tso Cai Lag Luam (MAA) kuj tau xa mus rau European Medicines Agency (EMA).
Piv nrog liraglutide, semaglutide muaj cov saw ntev aliphatic thiab muaj zog hydrophobicity, tab sis semaglutide tau hloov kho nrog cov saw luv ntawm PEG, thiab nws cov hydrophilicity tau txhim kho zoo heev.Tom qab kev hloov kho PEG, nws tuaj yeem tsis tsuas yog khi ze rau albumin, npog qhov chaw enzymatic hydrolysis ntawm DPP-4, tab sis kuj txo lub raum excretion, ua kom ntev lub neej ib nrab, thiab ua tiav cov txiaj ntsig ntev.
Daim ntawv thov
Semaglutide yog ib daim ntawv siv ntev ntev uas tsim los ntawm cov qauv ntawm liraglutide, uas zoo dua rau kev kho mob ntshav qab zib hom 2.
Bioactivity
Semaglutide (Rybelsus, Ozempic, NN9535, OG217SC, NNC0113-0217) yog ib qho kev ua haujlwm ntev glucagon-zoo li peptide 1 (GLP-1) analog, agonist ntawm GLP-1receptor, nrog rau hom 2 Kev kho mob zoo ntawm ntshav qab zib mellitus (TDM2). ).
Qhov System
Feem ntau, kev ua haujlwm zoo thiab kev lees paub yog nyob rau hauv qhov chaw npog tag nrho cov theem ntawm kev tsim cov khoom tiav.Kev tsim khoom tsim nyog thiab kev tswj xyuas kev ua haujlwm tau ua raws li cov txheej txheem pom zoo / cov lus qhia tshwj xeeb.Kev hloov pauv kev tswj hwm thiab kev sib txawv ntawm kev tuav tswj yog nyob rau hauv qhov chaw, thiab qhov tsim nyog kev ntsuam xyuas thiab kev tshawb nrhiav tau ua.Cov txheej txheem tsim nyog yog nyob rau hauv qhov chaw los xyuas kom meej cov khoom zoo ua ntej tso tawm rau hauv kev ua lag luam.
