Carbetocin los tiv thaiv kev cog lus uterine thiab kev ua haujlwm tom qab yug menyuam
Khoom Qhia Qhia
| Lub npe | Carbetocin |
| Tus lej | 37025-55-55-1 |
| Molecular Cov Qauv | C45h69N11O12s |
| Molecular hnyav | 988.17 |
| Einecs tooj | 253-312-6 |
| Kev Sib Hloov Tshwj Xeeb | D -69.0 ° (C = 0.25 hauv 1m acetic acid) |
| Kub taw tes | 1477.9 ± 65.0 ° C (kwv yees) |
| Ceev | 1.218 ± 0.06 g / cm3 (kwv yees) |
| Kev Cia | -15 ° C |
| Puab | hmoov |
Txhais lus hais tias
BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDEBONDBETWEENBUTYRYL-4-YLANDCYS); Butyryb-tyr (kuv)-pob-gln-asn-cys-pro-leu-leu-leu-leu-leu-nh2trifluoroacetatesalt; (Butyryb1, Tyr (kuv) 2) -1-carbaoxytoc intrifluoroacetatesaltaltaltaltanded; (Butyryl1, Tyr (kuv) 2) -OXYTOCIN; (Butyryl1, Tyr (kuv) 2) -OXYTOCINTRFFifuoroacetatesaltanduatesalt; Carbetocin; Carbetocintrifuluoroacetatesaltaltalt; (2-o-methyltyrosine) -De-amino-1-carbaoxytocin
Kev ua haujlwm biological
Carbetocin, ib tug oxytocin (OT) analog, yog Oxytocin Receptor Egonist nrog KI ntawm 7.1 nm. Carbetocin muaj ib qho siab (KI = 1.17 μm) Carbetocin muaj peev xwm rau kev tshawb fawb hemorrhate. Carbetocin tuaj yeem nkag mus rau cov ntshav.
Rooj mov
Carbetocin yog cov khoom siv hluav taws xob ntev-ua rau oxytocin 8-peptide analog nrog cov khoom siv tsis zoo, thiab lub chaw muag tshuaj thiab lub chaw muag tshuaj zoo ib yam li cov oxytocin zoo ib yam. Zoo li Oxytocin, Carbetocin khi rau cov tshuaj hormone receptors ntawm uterine du cov leeg, ua kom muaj cov suab nrov thiab ua kom nce siab dua ntawm cov ntawv qub. Oxytocin cov qib receptor nyob rau hauv lub tsev menyuam oxyptor nyob rau hauv lub xeev tsis muaj cev xeeb tub, nce thaum lub cev xeeb tub, thiab ncua sij hawm thaum lub sijhawm ua haujlwm. Yog li ntawd, carbetocin tsis tau cuam tshuam rau cov tsis yog lub cev xeeb tub, tab sis muaj lub zog Uterine cog lus rau lub tsev menyuam cev xeeb tub thiab cov tshiab tsim tsa Uterus.
Hloov Lwm Yam
Kev hloov pauv tau tswj hwm raws li cov txheej txheem. Raws li kev cuam tshuam thiab kev pheej hmoo thiab qhov mob hnyav, hloov pauv tau cais raws li cov loj, me thiab thaj chaw. Tus xaib hloov pauv tau me ntsis ntawm kev nyab xeeb thiab cov khoom lag luam zoo, thiab yog li ntawd tsis xav tau kev pom zoo thiab ceeb toom rau cov qhua tuaj noj mov; Cov kev hloov me me muaj kev cuam tshuam me ntsis rau kev nyab xeeb thiab cov khoom lag luam zoo, thiab yuav tsum ceeb toom rau cov qhua tuaj noj mov; Cov kev hloov loj tau cuam tshuam ntau dua rau kev nyab xeeb thiab cov khoom lag luam zoo, thiab xav tau kev pom zoo los ntawm cov qhua tuaj noj mov.
Raws li cov txheej txheem, kev hloov pauv tau pib nrog kev hloov daim ntawv thov uas hloov cov ntsiab lus thiab muaj kuab rau kev hloov pauv tau piav qhia. Qhov kev ntsuam xyuas yog tom qab ua tom qab daim ntawv thov, uas yog ua los ntawm kev hloov pauv chaw tswj hwm. Lub caij no, cov kev hloov pauv hloov tau faib rau qib loj, qib kawm qib siab thiab qib qis. Tom qab qhov kev ntsuam xyuas tsim nyog tau raws li kev faib tawm, txhua qib kev hloov pauv yuav tsum tau pom zoo los ntawm tus thawj tswj hwm DA. Txoj kev hloov pauv hloov tau tua tom qab kev pom zoo raws li kev npaj ua. Qhov hloov pauv hloov yog thaum kawg kaw tom qab QA tshaj tawm cov kev hloov pauv tau tsim nyog siv. Yog tias muaj kev ceeb toom rau cov neeg siv khoom, tus neeg yuav tsum tau qhia txog kev hloov pauv thaum pom zoo
