Li li linaclopotide rau cov plab zom mov hauv plab hnyuv 851199-59-2
Khoom Qhia Qhia
| Lub npe | Linaclotride |
| Tus lej | 851199-59-2 |
| Molecular Cov Qauv | C59H79N15o21S6 |
| Molecular hnyav | 1526.74 |
Txhais lus hais tias
Linacllotide; linaclotide; linaelotide; linaelotide; l-cysteinyl-l-α-glutamyl-l-tyrosyl -L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-,cyclic(1→6),(2→10),(5→13)-tris(disulfide)
Kev piav txog
Linaclotide, ib qho khoom siv hluavtaws peptide uas muaj 14 amino acids, muaj feem xyuam rau kev kho ntshav khov kho (g)
Tshuaj Tshuaj Muaj Zog
LinacLotide yog ib tug dawb kom tawm-dawb amorphous hmoov; Soluble me ntsis hauv dej thiab aqueous sodium tshuaj dawb tshuaj (0.9%).
Nws ua haujlwm li cas
LinacLotide yog Guananlate Cyclase-C Cov Receptor Egonist (GCCA) nrog ob qho tib si visceral analgesic thiab endocrine kev ua si. Ob lubnacvotide thiab nws cov metabolite nquag tuaj yeem khi rau cov Guananlate Cyclase-c (GC-C) receptor nyob rau ntawm lub plab hnyuv epithelium. Nyob rau hauv cov qauv tsiaj, linaclotride txo cov kab mob visceralin thiab ua rau tib neeg, thiab hauv tib neeg, cov tshuaj kuj tseem yuav nce colonic Transit. Qhov tshwm sim ntawm GC-C ua kom tau nce ntxiv inacellular thiab extracellular cgmp (cyclic guanosine monophosphate) ntau. Extracellular CGMP tuaj yeem txo cov kev ua si ntawm kev mob hlwb ntawm cov leeg mob thiab tshuaj xyuas kom pom tseeb hauv cov tsiaj txhu qauv. Intracellular CGMP tuaj yeem nce cov kev tso tawm ntawm chloride thiab bicarbonate hauv kev ua haujlwm ntawm cov hnyuv ntxig (cystic fibras)
Cov FAQ
Koj puas tuaj yeem lav kev nyab xeeb thiab nyab xeeb ntawm cov khoom lag luam?
Yog lawm, peb ib txwm siv cov ntim export zoo. Peb tseem siv cov phom sij tshwj xeeb ntim rau cov khoom lag luam txaus ntshai thiab siv cov khoom lag luam txias rau cov khoom kub siv cov khoom kub. Tus kws tshaj lij ntim thiab ntim cov khoom tsis muaj qauv ntxiv tuaj yeem them tus nqi ntxiv.
Yuav ua li cas txog cov nqi thauj khoom?
Tus nqi thauj khoom them nqi yog nyob ntawm txoj kev uas koj xaiv kom tau txais cov khoom muag. Qhia tawm ib txwm yog qhov nrawm tshaj plaws tab sis kuj tseem kim tshaj plaws. Los ntawm kev thauj khoom hiav txwv yog qhov kev daws teeb meem zoo tshaj plaws rau cov nyiaj ntau. Cov nqi thauj ncaj ncees raws nraim peb tsuas yog muab rau koj yog tias peb paub cov ntsiab lus ntawm cov nyiaj, qhov hnyav thiab txoj kev. Thov hu rau peb kom paub ntxiv.
