Ganirelix Acetate Peptide API
Product Detail
| Lub npe | Ganirelix Acetate |
| CAS nr | 123246-29-7 |
| Cov mis mos molecular | C80H113ClN18O13 |
| Molecular hnyav | 1570.34 Nws |
Synonyms
Ac-DNal-DCpa-DPal-Ser-Tyr-DHar(Et2)-Leu-Har(Et2)-Pro-DAla -NH2;Ganirelixum;ganirelix Acetate; GANIRELIX; Ganirelix Acetate USP/EP/
Kev piav qhia
Ganirelix yog ib qho hluavtaws decapeptide compound, thiab nws cov ntsev acetate, Ganirelix acetate yog gonadotropin-tso cov tshuaj hormone (GnRH) receptor antagonist. Cov amino acid sequence yog: Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-Tyr-D-HomoArg(9,10-Et2)-Leu-L-HomoArg(9,10-Et2)-Pro-D- Ala-NH2. Feem ntau hauv kev kho mob, nws yog siv rau cov poj niam uas tau txais kev pabcuam kev tsim cov cuab yeej siv tshuaj tiv thaiv zes qe menyuam los tiv thaiv kev ua haujlwm ntxov ntxov ntawm luteinizing hormone peaks thiab kho cov kab mob fertility vim qhov no. Cov tshuaj muaj cov yam ntxwv ntawm qhov tsis zoo tshwm sim tsawg, kev xeeb tub siab thiab lub sijhawm kho luv luv, thiab muaj qhov pom tseeb zoo piv nrog cov tshuaj zoo sib xws hauv kev kho mob.
Pharmacological Action
Lub pulsatile tso tawm ntawm gonadotropin-tso hormone (GnRH) nkoos lub synthesis thiab secretion ntawm LH thiab FSH. Qhov zaus ntawm LH pulses nyob rau hauv nruab nrab thiab lig follicular theem yog kwv yees li 1 ib teev. Cov pulses no tau tshwm sim nyob rau hauv ib ntus nce hauv cov ntshav LH. Thaum lub sij hawm ib nrab ntawm kev coj khaub ncaws, qhov tso tawm loj ntawm GnRH ua rau muaj qhov nce ntawm LH. Lub midmenstrual LH surge tuaj yeem ua rau ntau qhov kev xav ntawm lub cev, suav nrog: ovulation, oocyte meiotic resumption, thiab corpus luteum tsim. Kev tsim ntawm lub corpus luteum ua rau cov ntshav progesterone nce, thaum qib estradiol poob. Ganirelix acetate yog GnRH antagonist uas sib tw thaiv GnRH receptors ntawm pituitary gonadotrophs thiab lwm txoj hauv kev hloov pauv. Nws ua rau sai, thim rov qab inhibition ntawm gonadotropin secretion. Cov nyhuv inhibitory ntawm ganirelix acetate ntawm pituitary LH secretion muaj zog dua li ntawm FSH. Ganirelix acetate ua tsis tau tejyam rau induce thawj tso tawm ntawm endogenous gonadotropins, raws li antagonism. Kev ua kom tiav ntawm pituitary LH thiab FSH qib tshwm sim hauv 48 teev tom qab txiav tawm ganirelix acetate.
