Lub npe | Nyob rau hauv |
Tus lej | 90779-69-4 |
Molecular Cov Qauv | C43h67n11o12s2 |
Molecular hnyav | 994.19 |
Einecs tooj | 806-815-5 |
Kub taw tes | 1469.0 ± 65.0 ° C (kwv yees) |
Ceev | 1.254 ± 0.06 g / cm3 (kwv yees) |
Kev Cia | -20 ° C |
So | H2O: ≤100 MG / ML |
Ntawm atosiban acetate yog ib qho disulfide-sib tsoo cyclic polypectide muaj ntawm 9 amino acids. Nws yog hloov kho oxytocin molecule ntawm txoj haujlwm 1, 2, 4 thiab 8. Tus n-terminions [D-Tyr (et)] 2, thiab atosiban acetate yog siv nyob rau hauv cov tshuaj uas kua txiv ntoo nws muaj nyob rau hauv daim ntawv ntawm ib tug ntawm cov ntsev cov ntsev, feem ntau hu ua atosiban acetate.
Atosiban yog Oxytoporin thiab Vasopressin V1A ua ke recepor antagonist, tus Oxytocin receptor yog qauv zoo ib yam li Vasopressin v1a receptor. Thaum Oxytocin lub receptor yog thaiv, oxytocin tseem tuaj yeem ua los ntawm ib lub sijhawm ntawm ob lub receptor tau zoo nyob rau hauv kev siv tau dawb huv. Qhov no tseem yog ib qho ntawm cov laj thawj tseem ceeb vim li cas β-receptor agonists tsis tuaj yeem ua haujlwm tsis muaj kev cuam tshuam rau kev pab txhawb nqa uterine.
Atosiban yog ib qho kev sib tw ua ke ntawm Oxytocin thiab Vasopressin V1A, yog tias thaiv cov qauv tshuaj lom neeg ntawm Oxytocin thiab Vasopressin thiab txo cov kev mob siab.