Leuprorelin acetate tswj kev zais ntawm gonadal cov tshuaj hormones
Khoom Qhia Qhia
| Lub npe | LeUprorelin |
| Tus lej | 53714-56-0 |
| Molecular Cov Qauv | C59H84n16o12 |
| Molecular hnyav | 1209.4 |
| Einecs tooj | 633-395-9 |
| Kev Sib Hloov Tshwj Xeeb | D25 -31.7 ° (C = 1 hauv 1% acetic acid) |
| Ceev | 1.44 ± 0.1 g / cm3 (kwv yees) |
| Chaw Cia Khoom | -15 ° C |
| Puab | Huv |
| Acidity Coefficient | (PMA) 9.82 ± 0.15 (kwv yees) |
| Dej solubility | Soluble hauv dej ntawm 1mg / ml |
Txhais lus hais tias
Lh-rhleupridide; leupprolide (tib neeg); leuprorelin; LeuProrelin; LeuProrelin; -Ntau9) -luthizinghizone-tso tawm txoj kev hloov pauv;
Pharmacological effect
Leupyrolide, Goserelin, Triprelin, thiab Nafarelin yog ob peb cov tshuaj feem ntau yog siv ovaries rau kev kho mob ua mob cancer thiab prostate cancer. (raug xa mus ua Gnrh-ib cov tshuaj), cov tshuaj GNRH yog zoo sib xws hauv GNRH thiab sib tw nrog pituitary gnrh recepth. Ntawd yog, tus gonadotropin zais cia los ntawm lub pituitary zais cia, uas ua rau muaj kev txo qis hauv tus txiv neej pw tsis zais los ntawm lub zes qe menyuam.
Leuprotropide yog Gonadotropin-tso cov tshuaj hormones (GNRH) analog, ib peptide muaj ntawm 9 amino acids. Cov khoom no tuaj yeem ua kom muaj nuj nqi ua haujlwm ntawm cov hauj lwm pituitary-gonadal, thiab kev ua haujlwm ntawm kev txhawb nqa ntawm Luteinizing cov tshuaj Luteinizing muaj txog 20 zaug ntawm GNRH. Nws tseem muaj cov nyhuv muaj zog loj nyob rau hauv pituitary-gonad muaj nuj nqi dua li GNRH. Nyob rau hauv thawj theem ntawm kev kho, follicle stimulating hormone (FSRogen lossis Androgen yog inhibited, vim yog kev cia siab rau kev sib deev cov tshuaj hormones. Cov kab mob kev sib deev (xws li mob qog nqaij hlav cancer, endometriosis, thiab lwm yam) muaj kev kho mob.
Tam sim no, lub acetate ntsev ntawm leuprotrolide yog tsuas yog siv clinically, vim tias kev ua tau zoo ntawm Leuprodes yog qhov ruaj khov nyob rau hauv chav tsev kub. Cov kua yuav tsum muab pov tseg. Nws tuaj yeem siv rau kev kho mob castometriosis thiab Uterine Fibroids, Central Cancer Mob Cancer thiab Progressure Tus Mob Cancer thiab Progrificate rau kev kho cov tshuaj hormational. Nws kuj tseem tuaj yeem siv ua ntej ua ntej pib ua ntej rov qab, uas tuaj yeem ua tau cov khoom siv tau yooj yim, txo cov edemetrium, thiab txo qhov nyuaj ntawm kev phais mob.
