Daptomycin 103060-53-3 rau Kab Mob Sib Kis
Product Detail
| Lub npe | Daptomycin |
| CAS nr | 103060-53-3 |
| Cov mis mos molecular | C72H101N17O26 |
| Molecular hnyav | 1620.67 Nws |
| EINECS Number | 600-389-2 |
| Melting point | 202-204 ° C |
| Boiling point | 2078.2 ± 65.0 ° C (Predicted) |
| Qhov ntom | 1.45 ± 0.1 g / cm3 (Kev kwv yees) |
| Flash point | 87 ℃ |
| Cia tej yam kev mob | Muab ntim rau hauv qhuav, Khaws rau hauv lub freezer, hauv qab -20 ° C |
| Solubility | Methanol: soluble 5mg / ml |
| Acidity coefficient | (pKa) 4.00 ± 0.10 (Predicted) |
| Daim ntawv | hmoov |
| Xim | colorless rau faint daj |
Synonyms
N-[N-(1-Oxodecyl)-L-Trp-D-Asn-L-Asp-]-cyclo[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp- Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-4-(2-aminophenyl)-4-oxo-L-Abu-]; N-[N-Decanoyl-L-Trp- D-Asn-L-Asp-]-cyclo[Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L- Glu-]-3-(2-aminobenzoyl)-L-Ala-]; N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L- α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-benzenebutanoicacid(13-4)lactone; DAPTOMYCINE; Dapcin; Daptomycin,> = 99%; DaptomycinReadyMadeSolution; Daptomycin (LY146032)
Kev piav qhia
Cov tshuaj tua kab mob daptomycin yog cov tshuaj tua kab mob cyclic lipopeptide nrog cov qauv tshiab muab rho tawm los ntawm fermentation broth ntawm Streptomyces (S. reseosporus), uas cuam tshuam cov biosynthesis ntawm cov kab mob cell phab ntsa peptidoglycan los ntawm kev cuam tshuam kev thauj cov amino acids nyob rau hauv lub cell membrane.Hloov cov khoom ntawm cytoplasmic membrane tuaj yeem cuam tshuam cov kab mob ua haujlwm hauv ntau txoj hauv kev thiab tua cov kab mob Gram-zoo sai.Ntxiv rau nws lub peev xwm los ua cov kab mob Gram-positive feem ntau, daptomycin tseem ceeb dua rau cov kab mob sib cais uas tau pom tias tsis kam mus rau methicillin, vancomycin, thiab linezolid hauv vitro.Nws muaj cov haujlwm muaj zog, thiab cov cuab yeej no muaj qhov cuam tshuam tseem ceeb heev rau cov neeg mob hnyav.Eosinophilic pneumonia yog ib yam kab mob uas tsis tshua muaj thiab hnyav heev nrog cov tsos mob xws li ua npaws, hnoos, ua tsis taus pa, thiab ua pa nyuaj.
Antibacterial nyhuv
Daptomycin muaj cov kab mob zoo bacteriostatic tiv thaiv ntau yam kab mob-tiv taus, xws li MIC = 0.06-0.5 μg / ml rau methicillin-resistant Staphylococcus aureus (MRSA), thiab methicillin-resistant Staphylococcus aureus (MRSA).MIC = 0.0625～1μg/ml rau cov kab mob, MIC = 0.12～0.5μg/ml rau oxacillin-resistant Staphylococcus epidermidis, MIC = 2.5μg/ml rau enterococcus heev resistant rau aminoglycoside tshuaj tua kab mob, MIC = 2.5μg/ml rau Gm ntawm Enterococcus yog 0.5 ~ 1μg / ml, thiab MIC ntawm Enterococcus resistant rau glycopeptide tshuaj tua kab mob yog 1 ~ 2μg / ml.
