Lub npe | Caspofungin |
CAS nr | 162808-62-0 |
Cov mis mos molecular | C52H88N10O15 |
Molecular hnyav | 1093.31 Nws |
EINECS Number | 1806241-263-5 |
Boiling point | 1408.1 ± 65.0 ° C (Predicted) |
Qhov ntom | 1.36 ± 0.1 g / cm3 (Kev kwv yees) |
Acidity coefficient | (pKa) 9.86 ± 0.26 (Predicted) |
CS-1171;Caspofungine; CASPOFUNGIN; CASPOFUNGIN; PneuMocandinB0,1-[(4R,5S)-5-[(2-aMinoethyl)aMino]-N2-(10,12-diMethyl-1-oxotetradecyl)-4-hydroxy- L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-;CaspofunginMK-0991;Aids058650;Aids-058650
Caspofungin yog thawj echinocandin pom zoo rau kev kho mob ntawm cov kab mob fungal.Hauv vitro thiab hauv vivo kev sim tau lees paub tias caspofungin muaj cov tshuaj tua kab mob zoo tiv thaiv cov kab mob tseem ceeb-Candida thiab Aspergillus.Caspofungin tuaj yeem cuam tshuam cov phab ntsa ntawm tes los ntawm inhibiting cov synthesis ntawm 1,3-β-glucan.Clinically, caspofungin muaj txiaj ntsig zoo rau kev kho mob ntawm ntau yam candidiasis thiab aspergillosis.
(1,3)-D-glucan synthase yog ib qho tseem ceeb ntawm cov kab mob hu ua fungal cell synthesis, thiab caspofungin tuaj yeem ua rau cov kab mob fungal los ntawm kev tsis sib tw inhibiting cov enzyme no.Tom qab kev tswj hwm txoj hlab ntshav, cov tshuaj plasma concentration poob sai vim yog cov ntaub so ntswg faib, tom qab ntawd maj mam tso cov tshuaj los ntawm cov ntaub so ntswg.Metabolism ntawm caspofungin tau nce nrog cov koob tshuaj nce ntxiv thiab tau hais txog koob tshuaj nyob rau lub sijhawm kom nyob ruaj khov nrog ntau koob tshuaj.Yog li ntawd, txhawm rau kom ua tiav qib kev kho mob zoo thiab zam kev sib xyaw tshuaj, thawj koob tshuaj yuav tsum tau ua raws li kev noj tshuaj.Thaum siv cytochrome p4503A4 inducers tib lub sijhawm, xws li rifampicin, carbamazepine, dexamethasone, phenytoin, thiab lwm yam, nws raug nquahu kom nce koob tshuaj ntawm caspofungin.
FDA pom zoo cov lus qhia rau caspofungin suav nrog: 1. Ua npaws nrog neutropenia: txhais tau tias: kub taub hau> 38 ° C nrog cov neutrophil suav (ANC) ≤500 / ml, lossis nrog ANC ≤1000 / ml thiab nws tau kwv yees tias nws tuaj yeem txo qis. rau qis dua 500 / ml.Raws li kev pom zoo ntawm Lub Koom Haum Kab Mob Sib Kis ntawm Asmeskas (IDSA), txawm hais tias cov neeg mob ua npaws tsis tu ncua thiab neutropenia tau kho nrog cov tshuaj tua kab mob dav dav, cov neeg mob uas muaj kev pheej hmoo siab tseem pom zoo kom siv empiric antifungal therapy, suav nrog caspofungin thiab lwm yam tshuaj tua kab mob. ..2. Invasive candidiasis: IDSA pom zoo echinocandins (xws li caspofungin) ua cov tshuaj xaiv rau candidemia.Nws kuj tseem siv tau los kho cov kab mob hauv plab, kab mob peritonitis thiab mob hauv siab los ntawm tus kab mob Candida.3. Esophageal candidiasis: Caspofungin tuaj yeem siv los kho esophageal candidiasis hauv cov neeg mob refractory lossis intolerance rau lwm yam kev kho mob.Ntau qhov kev tshawb fawb tau pom tias qhov kev kho mob ntawm caspofungin yog piv rau fluconazole.4. Invasive aspergillosis: Caspofungin tau txais kev pom zoo rau kev kho mob aspergillosis invasive aspergillosis nyob rau hauv cov neeg mob intolerance, tsis kam, thiab ineffectiveness ntawm lub ntsiab antifungal tshuaj, voriconazole.Txawm li cas los xij, echinocandin tsis pom zoo raws li kev kho thawj kab.