Daptomycin 103060-53-3 Rau cov kab mob sib kis
Khoom Qhia Qhia
| Lub npe | Daptomycin |
| Tus lej | 103060-53-3 |
| Molecular Cov Qauv | C72h101n1n17o26 |
| Molecular hnyav | 1620.67 |
| Einecs tooj | 600-389-2 |
| Melting taw tes | 202-204 ° C |
| Kub taw tes | 2078.2 ± 65.0 ° C (kwv yees) |
| Ceev | 1.45 ± 0.1 g / cm3 (kwv yees) |
| Flash point | 87 ℃ |
| Kev Cia | Muab ntim rau hauv qhuav, khaws rau hauv lub freezer, hauv qab -20 ° C |
| So | Methanol: Soluble5Mg / ml |
| Acidity Coefficient | (PMA) 4.00 ± 0.10 (kwv yees) |
| Puab | hmoov |
| Xim | tsis muaj kob kom tsaus muag daj |
Txhais lus hais tias
N- [N- (1-Oxodecyl) -L-Trp-D-Asn-L-Asp - L-Asp *-As-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-ill ;N-[N-Decanoyl-L-Trp-D-Asn-L-Asp-]-cyclo[Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-3-(2-aminobenzoyl)-L-Ala-];N-(1-Oxod ECyl)-cov tryptophyl-d-aspparaginyl-l-α-aspartyl-l-α-aspartyll-l-α-aspartylglycyl-d-seryl- (3r) -3-methyl-l-α- Glutamyl-α, 2-diamo-γ-oxo-oxo-oxo-oxo-oxo-oxo; Daptomycin, Daptomycin, DaptomycinSadyolute; DaptonMeGe
Kev piav txog
Cov tshuaj tua kab mob los ntawm cov kab mob laspietide nrog cov qauv ntawm cov kab mob cell peptidoglycan los ntawm kev cuam tshuam cov amino acids nyob rau hauv lub cell membrane. Hloov kho cov khoom ntawm cytoplasmic mem tes tuaj yeem cuam tshuam cov kab mob membrane ua haujlwm hauv ntau txoj kev thiab tua cov kab mob gram-zoo. Ntxiv rau nws lub peev xwm los ua cov kab mob uas cuam tshuam tshaj plaws, Dintomycin tseem ceeb tshaj rau cov tshuaj tua kab mob uas tau qhia txog Millings me me, Vancomycin, thiab Kab hauv Vitro. Nws tau muaj zog ua haujlwm, thiab cov khoom no muaj qhov chaw kuaj mob tseem ceeb heev rau cov neeg mob mob. EOSinophilic ntsws yog qhov tsis tshua muaj mob thiab mob hnyav nrog ua pa, hnoos, ua pa nyuaj.
Cov nyhuv tua kab mob
Daptomycin muaj kev ua haujlwm zoo tiv thaiv ntau yam tshuaj tua kab mob, xws li Micreesicillin-Resistant Staphyncoccus aureus (MRSA). Mic = 0.0625 ~ 1μg / ml rau cov kab mob, mic = mL rau oxacillin-Resistant Staphyncus epidermiS, mic = ml rau gmrbia -taws mol ntawm enterococcus yog 0.5 ~ 1μg / ml, thiab mic sup enterococcus tiv taus glycopeptide tshuaj tua kab mob yog 1 ~ 2μg / ml.
