ua
Lub npe | Chondroitin sulfate |
CAS nr | 9007-28-7 |
Cov mis mos molecular | C13H21NO15S |
Molecular hnyav | 463.36854 ib |
EINECS Number | 232-696-9 |
Dej solubility | Soluble hauv dej |
Purity | 98% |
Cia | Khaws ntawm qhov kub thiab txias |
Daim ntawv | Hmoov |
Xim | Dawb mus rau dawb |
Ntim | PE hnab + Aluminium hnab |
poly-1(2/3)-n-acetyl-2-amino-2-deoxy-3-o-beta-d-glucopyranurosyl-4-(6) sulfonyl-d-galactose;chondroitinpoly sulfate;chondroitin sulfates;chondroiti nsulfuricacid;chondroitin sulfuric acids;chossurid;CSO; (5ξ)-2-(Carboxyamino)-2-deoxy-3-O-β-D-glucopyranuronosyl-4-O-sulfo-α-L-arabino-hexopyranose
Kev piav qhia
Chondroitinsulfate (CS) yog ib qho acidic mucopolysaccharide rho tawm thiab purified los ntawm cov tsiaj pob txha mos.Chondroitin sulfate muaj cov qauv sib txawv xws li A, C, D, E, H thiab K. Chondroitin sulfate nyob rau hauv cov xwm feem ntau pom muaj nyob rau hauv cov tsiaj pob txha, caj pas, pob txha qhov ntswg (41% hauv npua), bovine, nees septum thiab trachea (muaj 36% mus rau 39%), lwm cov ntaub so ntswg xws li cov pob txha ceg, ligaments, tawv nqaij, pob txha, thiab lwm yam.Cov ntsiab lus ntawm cov pob txha ntses yog nplua nuj heev, xws li 50% mus rau 60% hauv cov pob txha shark, thiab tsawg heev hauv cov ntaub so ntswg.
Rau cov kab mob coronary atherosclerotic, nce ntshav lipids thiab roj cholesterol, arteriosclerosis, angina pectoris, myocardial ischemia, myocardial infarction, thiab lwm yam hauv cov neeg mob plawv.
Pharmacological Action
Rapamycin (RAPA) muaj cov kev mob tshwm sim zoo sib xws rau FK506.Hauv ntau qhov kev sim tshuaj ntsuam xyuas, nws cov kev mob tshwm sim tau pom tias yog koob tshuaj thiab thim rov qab, thiab RAPA ntawm cov tshuaj kho tsis tau pom tias muaj nephrotoxicity tseem ceeb thiab tsis muaj gingival hyperplasia.Cov tshuaj lom thiab cov kev mob tshwm sim tseem ceeb muaj xws li: mob taub hau, xeev siab, kiv taub hau, ntshav ntswg, thiab mob pob qij txha.Kev kuaj mob txawv txav xws li: thrombocytopenia, leukopenia, qis hemoglobin, hypertriglyceridemia, hypercholesterolemia, hyperglycemia, siab siab enzymes (SGOT, SGPT), elevated lactate dehydrogenase, hypokalemia, Hypomagnesemia, thiab lwm yam. Tsis ntev los no daim tawv muag tau tshaj tawm ua rau cov edema ntawm daim tawv nqaij thiab RA. plasma phosphate theem tau xav tias yuav ncua ntev phosphate excretion los ntawm lub raum hloov los ntawm RAPA-based immunosuppressive therapy.Zoo ib yam li lwm cov tshuaj tiv thaiv kab mob, RAPA muaj feem kis tau tus kab mob ntau ntxiv, nrog rau kev tshaj tawm txoj kev nyiam ua rau mob ntsws tshwj xeeb, tab sis qhov tshwm sim ntawm lwm yam kab mob kis tau zoo tsis txawv ntawm CsA.
Toxicological teebmeem
Chondroitin sulfate dav muaj nyob rau hauv tib neeg thiab tsiaj pob txha mos.Kev npaj tshuaj tsuas yog muaj ob isomers ntawm chondroitin sulfate A thiab chondroitin sulfate C, thiab cov ntsiab lus ntawm chondroitin sulfate nyob rau hauv cov pob txha ntawm cov tsiaj ntawm ntau hom thiab muaj hnub nyoog sib txawv.Nws cov teebmeem pharmacological yog raws li hauv qab no: chondroitin sulfate tuaj yeem tshem tawm cov lipids thiab lipoproteins hauv cov ntshav, tshem tawm cov roj cholesterol los ntawm cov hlab ntsha nyob ib ncig ntawm lub plawv, tiv thaiv thiab kho atherosclerosis, thiab nce kev hloov pauv ntawm lipids thiab fatty acids hauv hlwb.Chondroitin sulfate tuaj yeem tiv thaiv thiab kho kab mob plawv.Nws muaj anti-atherosclerosis thiab anti-atherogenic plaque tsim los ntawm kev sim cov qauv arteriosclerosis;tsub kom lub coronary ceg los yog collateral ncig ntawm atherosclerosis, thiab yuav ua rau kom kev sim coronary arteriosclerosis los yog embolism.Kho, rov tsim dua tshiab thiab kho myocardial necrosis lossis degeneration.Nws tuaj yeem nce biosynthesis ntawm cell messenger ribonucleic acid (mRNA) thiab deoxyribonucleic acid (DNA) thiab muaj cov txiaj ntsig ntawm kev txhawb nqa cell metabolism.Tsawg ua haujlwm anticoagulant.Chondroitin sulfate muaj cov nyhuv anticoagulant nruab nrab, thiab txhua 1 mg ntawm chondroitin sulfate A yog sib npaug rau cov tshuaj tiv thaiv coagulant ntawm 0.45U ntawm heparin.Qhov kev ua haujlwm anticoagulant no tsis nyob ntawm cov tshuaj antithrombin III los ua nws lub luag haujlwm, nws tuaj yeem ua haujlwm anticoagulant los ntawm fibrinogen system.Chondroitin sulfate kuj muaj cov tshuaj tiv thaiv kab mob, ua kom lub qhov txhab kho thiab tiv thaiv qog.