Caspofungin rau Kab Mob Antifungal
Khoom Qhia Qhia
| Lub npe | Caspofunge |
| Tus lej | 162808-62-0 |
| Molecular Cov Qauv | C52H88N10o15 |
| Molecular hnyav | 1093.31 |
| Einecs tooj | 1806241-263-5 |
| Kub taw tes | 1408.1 ± 65.0 ° C (kwv yees) |
| Ceev | 1.36 ± 0.1 g / cm3 (kwv yees) |
| Acidity Coefficient | (PMA) 9.86 ± 0.26 (kwv yees) |
Txhais lus hais tias
CS-1171; caspoflungine; caspoflgin; pneumofginbginb0,1 - [((4-aminoethyl) amino] -Th- (10,12-dimethyl -1-oxotetradrecyl) -4-hydroxy-L-Ornithine]-5 ---L-Ornthofunginmk-0991; AIDS058650; AIDS-058650
Tshuaj Tshuaj Muaj Zog
Caspofungin yog thawj tus Echinocandin pom zoo rau kev kho tus kab mob uas tsis pom kev fungal. Hauv vitro thiab hauv Vivo kev sim paub tseeb tias caspoflungin muaj cov tshuaj tua kab mob zoo rau cov kab ke tseem ceeb ntawm cov kab ke tseem ceeb-candida thiab aspergillus. Caspofadgin tuaj yeem nqus tau lub xovtooj ntawm tes los ntawm inhibiting synthesis ntawm 1,3-β-glucan. Clinically, Caspofungin muaj cov txiaj ntsig zoo rau kev kho mob ntawm ntau yam kev sib cav thiab aspergillosis.
Ua rau
(1,3) -d-blucan synthease yog qhov tseem ceeb ntawm fungal cell phab ntsa hluav taws xob hluavtaws tuaj yeem ua rau cov tshuaj tiv thaiv kab mob uas tsis muaj kev sib tw ntawm cov enzyme no. Tom qab tswj hwm cov tshuaj tiv thaiv ntshav, cov tshuaj plasma tshuaj sai sai vim yog cov ntaub so ntswg faib, ua raws li cov tshuaj zuj zus ntawm cov nqaij. Cov metabolism ntawm caspofungade nce nrog ntau ntxiv cov koob tshuaj thiab tau tshuaj-ntsig txog lub sijhawm khov kho nrog ntau yam koob tshuaj. Yog li ntawd, txhawm rau ua tiav qib kev kho kom zoo thiab zam kev siv yeeb tshuaj ntxiv, ib qho kev thauj khoom thawj zaug yuav tsum tau ua raws los ntawm kev saib xyuas. Thaum siv Cytochrome P4503A4 tsis muaj nyob rau tib lub sijhawm, xws li Rifampine, carbameasone, phenytoin, thiab lwm yam.
Kev taw qhia
FDA-Pom Zoo Qhia Txog Caspofungin muaj xws li: 1. Ua npaws nrog neutropenia: ua npaws> 18 ° thiab nws tau kwv yees tias nws tuaj yeem raug txo qis mus rau hauv qab 500 / ml. Raws li kev pom zoo ntawm kev sib kis cov kabmob zej zog ntawm America (IMSA), txawm tias cov neeg mob tsis txaus ntseeg los siv cov tshuaj tiv thaiv kab mob loj thiab tsis muaj tshuaj tiv thaiv kab mob. Cov. 2. Kev tsis txaus ntseeg: Idsa Xav kom Echinocandins (xws li Caspofungin) raws li cov tshuaj xaiv rau Candidemia. Nws kuj tseem siv tau los kho cov pob txha hauv av hauv nroog, Peritonitis thiab mob hauv siab los ntawm tus kab mob Candida. 3. Esophageal candidiasis: Casopofungin tau siv los kho esophageal candidiasis hauv cov neeg mob uas muaj kev kho mob lossis kev mob siab rau lwm tus. Ntau cov kev tshawb fawb tau pom tias cov nyhuv kho mob ntawm caspofungin yog piv rau cov fluconazole. 4. Transpive aspergillosis: caspoflarginis tau pom zoo rau kev kho mob ntawm kev tsis txaus siab aspergillosis hauv cov tshuaj tiv thaiv tseem ceeb, voriconazole. Txawm li cas los xij, Echinocandin tsis pom zoo ua thawj zaug kev kho kab.
