Tianeptine sodium rau ntu kev chim siab

Kev siv

Nws tsuas yog ua raws li 5-ht system, tsis muaj kev txaus siab, ua kom loog, tiv thaiv kabmob thiab cardiotoxicity. Rau kev nyuaj siab.

Pharmacological effect

1. Cov tshuaj tiv thaiv kev ntxhov siab ntawm cov khoom no txawv ntawm cov tsoos tsoos ib txwm muaj. Nws tuaj yeem nce ntxiv up up of 5-ht hauv synaptic cleft, tab sis muaj cov nyhuv tsis muaj zog rau ntawm 5-ht thiab na. Tej zaum yuav muaj cov nyhuv ntawm kev txhim kho 5-HT Neuronal kis. Nws tsis muaj ib qho muaj ib zaug rau cov m receptors, H1, α1 thiab α2-li cov kheej kheej.
2. Cov antidepressant ua tau zoo ntawm cov khoom no zoo ib yam li TCA, thiab kev nyab xeeb thiab thev tau zoo dua TCA (Trricyclic antidepressants). Qhov ua tau zoo ntawm cov khoom no zoo ib yam li SSRI fluoxetine.
3. Kev sim tshuaj yeeb tshuaj tau pom tias nws tuaj yeem: nce qhov tshwm sim ntawm pyramidal thiab nrawm rov qab los ntawm nws txoj haujlwm tom qab kev txwv; Nce cov reabsorption ntawm 5-hydroxyboardcine los ntawm neurons hauv cortebral cortex thiab hippocampus.

Kev Tshawb Fawb Txog Kev Kawm Txuj Ci

- Mob siab, subacute thiab ntev-lub sij hawm kev sim ua ntej ntev: Tsis muaj kev hloov pauv hauv biology, nplooj siab muaj nuj nqi, pathological anatomy.
- Kev ua me nyuam yam toxicity thiab Teratogenicity Test: Teratogenicity Test: Tianeptine tsis muaj kev cuam tshuam rau kev ua me nyuam muaj peev xwm kho cov niam txiv thiab cov menyuam yaus.
- Mutagenicity xeem: Tianeptine tsis muaj cov nyhuv mutagenic.