Tadalafil 171596-296-29-5005 txhawm rau kho erectile kawg hauv cov txiv neej

Tadalafil (Tadalafil, Tadalafil) muaj cov mis ntawm C229n3O4 thiab qhov hnyav molecular ntawm 389.4. Nws tau siv dav hauv kev kho cov txiv neej erectile kawg txij li xyoo 2003, nrog lub npe lag luam cialis (cialis). Nyob rau lub Rau Hli 2009, FDA tau pom zoo Tadalafil hauv Tebchaws Meskas rau kev kho mob ntawm cov kev mob ntsws uas muaj kev lag luam adcirca. Tadalafil tau qhia nyob rau hauv 2003 raws li cov tshuaj rau kev kho mob ntawm Ed. Nws siv tau zoo 30 feeb tom qab kev tswj hwm, tab sis nws cov txiaj ntsig zoo tshaj yog 2th tom qab pib ntawm 36H, thiab nws cov nyhuv yuav tsis cuam tshuam los ntawm cov khoom noj. Cov koob tshuaj ntawm Tadalafil yog 10 lossis 20 mg, qhov kev pom zoo thaum pib yog 10 mg, thiab cov koob tshuaj raug muab kho tau raws li tus neeg mob cov lus teb thiab cov nyom. Kev tshawb fawb ua lag luam tau qhia tias tom qab tswj hwm qhov ncauj 10 lossis 20 mg ntawm Tadalafil rau 12 lub lis piam, tus nqi zoo yog 67% thiab 81%, feem. Ntau cov kev tshawb fawb tau qhia hais tias Tadalafil muaj kev ua tau zoo dua hauv kev kho mob ntawm Ed.

Erectile kawg: Tadalafil yog ib qho kev xaiv phosphodiesase Hom 5 (PDE5) xws li sildenafil, thiab cov kev noj haus ntau tsis cuam tshuam nrog nws nqus. Kev ua yeeb yam ntawm kev sib deev, nitric oxide synthease (Nos) hauv cov kab mob siab thiab vascular endotheskes catalesches lub synthesis ntawm cov syn synesis ntawm cov ox ox of ntawm lub substrate L-arginine. Tsis muaj kev qhib GuanSlate Cyclase, uas hloov siab Guanosine mus rau cyclicphaine monoxase, yog ua kom lub corne guanernosum erection tshwm sim vim yog so ntawm cov leeg du. Phosphodiesterase Hom 5 (PDE5) DEGRADES CGMP rau hauv cov khoom lag luam tsis muaj zog, ua rau tus qau mus rau hauv lub xeev tsis muaj zog. Tadalafil inhibits qhov teeb meem ntawm PDMP ntawm CGMP, uas relaxes cov leeg du cov leeg ntawm lub corpus cavernosum, ua rau Cwj chim erection. Txij li nitrates tsis muaj cov neeg pab nyiaj, sib xyaw nrog tadalafil yuav ua kom nce qib CGMP thiab ua rau mob siab rau cov neeg mob siab. Yog li ntawd, kev siv sib xyaw ntawm ob yog contraindicated hauv chaw kuaj mob.

Tadalafil ua haujlwm los ntawm kev ua haujlwm sib xyaw. GMP yog degraded, yog li siv tau siv nrog nitrates yuav ua rau huab cua siab poob rau hauv cov ntshav siab thiab nce kev pheej hmoo ntawm syncope. CYCE3PA4 INFUCERS yuav txo cov bioavailability ntawm tadanafil, thiab hvi protectorycin yuav ua rau cov ntshav ntawm cov tshuaj yuav tsum tau hloov kho. Txog tam sim no, tsis muaj kev tshaj tawm hais tias cov khoom siv hluav taws xob ntawm cov khoom no cuam tshuam los ntawm kev noj haus thiab cawv.