Sildenafil Citrate Treating Erectile Dysfunction 171599-83-0
Product Detail
| Lub npe | Sildenafil Citrate |
| CAS nr | 171599-83-0 |
| Cov mis mos molecular | C28H38N6O11S |
| Molecular hnyav | 666.70 ib |
| EINECS Number | 200-659-6 |
| Merck | 14, 8489 ib |
| Qhov ntom | 1.445g / cm3 |
| Kev cia khoom | 2-8 ° C |
| Daim ntawv | Hmoov |
| Xim | Dawb |
| Dej solubility | DMSO: > 20mg/mL |
Synonyms
Viagra, Sildenafil citrate; 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazinecitratesalt; 5-[2-Ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[5,4-e]pyrimidin-7-onecitratesalt; 1-[[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine,2-hydroxy-1,2,3-propanetricarboxylate; SildenafilCitrate (100 mg); Sildenafilcitrate,>= 99%; Sildenafilcitrate, Kev muab khoom; 5-[2-Ethoxy-5-[(4-methyl-piperazin-1-yl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-onecitrate
Pharmacological nyhuv
Pharmacological Action
Sildenafil citrate yog ib qho kev xaiv 5-phosphodiesterase inhibitor uas txhim kho nitric oxide-dependent, cyclic guanosine monophosphate-mediated pulmonary vasodilation los ntawm inhibiting kev tawg ntawm cyclic guanosine monophosphate. Ntxiv rau qhov ncaj qha nthuav dav ntawm cov hlab ntsha pulmonary, nws tuaj yeem tiv thaiv lossis thim rov qab vascular remodeling.
Cov cuab yeej tshuaj thiab kev siv
Sildenafil citrate, lub npe lag luam Viagre, feem ntau hu ua Viagra, yog cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) inhibitor uas tuaj yeem txhim kho erection tom qab tswj qhov ncauj. Sildenafil citrate tuaj yeem txhim kho cov nyhuv ntawm nitric oxide (NO) los ntawm inhibiting hom 5 phosphodiesterase uas decomposes cyclic guanosine monophosphate (cGMP) hauv corpus cavernosum. Nce qib ntawm cGMP nyob rau hauv lub corpus cavernosum, so cov nqaij mos nyob rau hauv lub corpus cavernosum, ua rau kom cov ntshav ntws, ncua lub sij hawm noov erection thiab ua kom lub firmness. Rau cov neeg mob impotence nrog erectile kawg. Cov neeg laus noj 50 mg ntawm qhov ncauj txhua zaus, mus txog 1 zaug hauv ib hnub, thiab siv raws li xav tau li ntawm 1 teev ua ntej kev sib deev. Qhov siab tshaj plaws yog 0.1g txhua lub sijhawm.
Hauv vivo kev tshawb fawb
Hauv cov dev uas tau tso tshuaj loog, Sildenafil citrate txhim kho qhov quav erectile ua haujlwm nyob rau hauv pelvic paj hlwb stimulation los ntawm ntsuas intracavernous siab. Sildenafil citrate reversed impaired carbamoylcholine-stimulated so thiab inhibited superoxide tsim nyob rau hauv cavernosal ntaub so ntswg ntawm hypercholesterolemic luav. Nyob rau hauv Sprague-Dawley nas, Sildenafil txhim kho erectile muaj nuj nqi nyob rau hauv lub sij hawm-dose-nyob ntawm tus yam ntxwv, nrog rau qhov zoo tshaj plaws rov tshwm sim nyob rau hnub 28 ntawm ib koob tshuaj ntawm 20 mg / kg ib hnub twg. Hauv Sprague-Dawley nas, kev tswj hwm ntawm Sildenafil tau ua rau cov leeg nqaij collagen sib piv thiab khaws cia ntawm CD31 thiab eNOS qhia. Hauv Sprague-Dawley nas, Sildenafil txo qis apoptotic Performance index thiab nce phosphorylation ntawm akt thiab eNOS piv nrog rau pawg tswj hwm.
