Sildenafil citrate kho erectile kawg 171599-83-0

Pharmacological txiav txim siab
Sildenafil citrate yog xaiv 5-phosphodiesase inhibores-doliding guanosine vasy guanosine monoposphate. Ntxiv rau kev nthuav dav ncaj qha ntawm cov hlab ntshav ntawm cov hlab ntshav, nws kuj tuaj yeem tiv thaiv lossis rov qab hloov kho txoj kev hloov pauv.

Medicinal thaj chaw thiab cov ntawv thov
Sildenafil citrate, lub npe hu ua lag luam Viagre, feem ntau yog hu ua Viagra, yog ib tug cyclicpiess (CGMP) -Specific uas muaj peev xwm txhim kho erection tom qab kev tswj hwm qhov ncauj. Sildenafil cus tau tuaj yeem txhim kho cov nyhuv ntawm nitric oxide (tsis muaj) los ntawm inhibiting pyclices cyclices monoposine monoposcate (CGMP) hauv lub Corpus Cavernum. Nce theem ntawm CGMP hauv Cornus Cavernosum, so cov leeg du hauv lub corneumernum, nce qhov dej ntawm cov chaw mos erection thiab nce cov kev ua kom ruaj khov thiab nce cov kev ua kom ruaj khov thiab nce qhov ruaj khov. Rau cov neeg mob impotence nrog erectile kawg. Cov neeg laus noj 50 mg thiab 1 lub sijhawm nyob rau ib hnub, thiab siv nws li xav tau li 1 teev ua ntej kev sib deev. Tus nqi siab tshaj yog 0.1g txhua lub sijhawm.

Hauv kev tshawb fawb Vivo
Hauv cov dev loog, sildenafil citrate txhim kho kom loj taub hau kev ua haujlwm nyob rau hauv plab mos txhawb nqa los ntawm kev ntsuas lub zog. Sildenafil citrate cim carbamoylchool-stimulated so thiab inhibited superoxide daim ntaub so ntswg ntawm hyperchholestercemic luav. Nyob rau hauv sprague-dawley nas, sildenafil txhim kho erectile muaj nuj nqi nyob rau hauv lub sij hawm-koob-dose-dose-dose tshwm sim rau hnub 28 ntawm ib koob ntawm 20 mg / kg ib hnub. Nyob rau hauv sprague-dawley nas, kev tswj hwm ntawm Sildenafil tau tshwm sim hauv cov leeg nqaij collagen sib zog txuag thiab khaws cia ntawm CD31 thiab Enoos qhia tawm. Nyob rau hauv sprague-dawley nas, Sildenafil tseem txo cov ntsuas apoptotic thiab nce cov phosphorholation ntawm AKT thiab EnOS piv nrog cov pab pawg tswj.