RapamyCycin yog tshuaj tiv thaiv kab mob, tshuaj tiv thaiv mob cancer thiab anti-laus
Khoom Qhia Qhia
| Lub npe | Rapamcin |
| Tus lej | 53123-88-9 |
| Molecular Cov Qauv | C51h79No13 |
| Molecular hnyav | 914.19 |
| Einecs tooj | 610-965-5 |
| Kub taw tes | 799.83 ° C (kwv yees) |
| Ceev | 1.0352 |
| Chaw Cia Khoom | Muab ntim rau hauv qhuav, khaws rau hauv lub freezer, hauv qab -20 ° C |
| Puab | Hmoov |
| Xim | Xim dawb |
| Yam ntim | PE hnab + Aluminium Hnab |
Txhais lus hais tias
AY 22989; 23H-pyrido (2,1-c) (1,4) OxaAzACTriacontine; Rapamycin; Rapamcin, Streptomycin; Rapamycopicus; RPM
Pharmacological effect
Kev piav txog
RapamyCy yog ib lub macrolide tshuaj tua kab mob uas muaj cov qauv sib xws sib xws rau ExcoFol (FK506), tab sis muaj lub imunosuppressive ntau me ntsis. FK506 inhibits qhov muaj peev xwm ntawm t University of Chicago Cov Kws Tshawb Fawb Kev Siv Cov Tshuaj Tiv Thaiv Kev Lag Luam rau Tebchaws Europe thiab cov neeg siv tshuaj tsis zoo, yog li ua kom muaj sia nyob ntawm cov neeg mob lub sijhawm. Studies have shown that rapamycin is easily decomposed by enzymes after entering the digestive tract, and grapefruit juice contains a large amount of furanocoumarins, which can inhibit the destructive effect of digestive tract enzymes on rapamycin. Tuaj yeem txhim kho cov bioavailability ntawm rapamycin. Nws tau hais tias cov kws kho mob dutch tshaj plaws tau pom cov kua txiv kab ntxwv muaj cov txiaj ntsig thiab tam sim no cov kws kho mob tau thov nws rau kev npaj rapamycin tau npaj ua ntej.
Nyob rau hauv xyoo tas los, kev tshawb fawb pom tau tias lub hom phiaj ntawm RapamyCin (Mtor) yog ib qho kev sib txawv ntawm nws txoj kev nrog txoj hauv kev nrog ntau txoj hauv kev. Raws li cov neeg inhibitor ntawm mtor, rapamcin tuaj yeem kho mob qog noj ntshav, muaj mob ntsws ntsws, suav nrog mob qog noj ntshav thiab mob plab. Tshwj xeeb tshaj yog nyob rau hauv kev kho mob ntawm ob qho kab mob tsawg, lam (lymphangyomyomycosis) thiab Lam thiab LC thiab QC thiab Las kuj tseem tuaj yeem suav tau cov kab mob qog mus rau qee yam.
Sab cuam
RapamyCy (Rapa) muaj cov kev mob zoo sib xws rau FK506. Nyob rau hauv ib tug loj ntawm cov kev sim tshuaj mob, nws cov kev mob tshwm sim tau pom kom muaj koob tshuaj tiv thaiv thiab rapa ntawm kho nepotoxicity thiab tsis muaj kev sib tw hingperplasia. Lub ntsiab mob lom thiab cov kev mob tshwm sim muaj: mob taub hau, xeev siab, kiv taub hau, taub ntswg, thiab mob sib koom tes. Kuaj cov khoom lag luam, tsis ntev los no, hypomagnese dezymia, istchacemia, hypomagnesemia, thiab lwm yam tawv muag istema, thiab lwm yam tawv muag Kev tswj hwm, thiab qhov ua rau muaj cov ntshav phosphamate qis yog xav ua lub raum ntev los ntawm lub raum ntev los ntawm rapa-raws li immunosuppressive kev kho. Zoo li lwm tus immunosuppressants, SCA tau muaj kev kis tau tus kab mob ntau ntxiv los ua mob ntsws, tab sis qhov tshwm sim ntawm lwm yam kev sib txawv tsis txawv ntawm CSA.
