Cov khoom
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High Purity Peptides Retatrutide 10mg rau poob phaus thiab ntshav qab zib
Purity:> 99%
Lub xeev: Lyophilized hmoov
Qhov tsos: Dawb hmoov
Specification: 5mg / 10mg / 15mg / 20mg / 30mg
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Retatrutide
Retaglutide yog ib qho tshiab dipeptidyl peptidase-4 (DPP-4) inhibitor chav kawm hypoglycemic tshuaj uas tuaj yeem tiv thaiv kev degradation ntawm glucagon-zoo li peptide-1 (GLP-1) thiab qabzib-dependent insulin-tso polypeptide (GIP) los ntawm DPP-4 enzyme hauv cov hnyuv thiab cov ntshav, ua rau lawv cov kev ua kom ntev ntev ntawm cov tshuaj insulin tsis pub muaj kev cuam tshuam. theem pib ntawm kev yoo mov insulin, thaum txo qis glucagon los ntawm pancreatic α hlwb, yog li tswj tau zoo dua tom qab cov ntshav qab zib. Nws ua tau zoo ntawm cov nyhuv hypoglycemic, kam rau ua, thiab ua raws.
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Inclisiran sodium
Inclisiran sodium API (Active Pharmaceutical Ingredient) yog kawm feem ntau hauv kev cuam tshuam ntawm RNA (RNAi) thiab kev kho mob plawv. Raws li ob-stranded siRNA lub hom phiaj ntawm PCSK9 noob, nws yog siv nyob rau hauv preclinical thiab soj ntsuam kev tshawb fawb los soj ntsuam cov gene-silencing lub tswv yim ntev rau txo LDL-C (tsawg-density lipoprotein cholesterol). Nws kuj tseem ua haujlwm ua qauv sib xyaw rau kev tshawb xyuas siRNA kev xa khoom, kev ruaj ntseg, thiab lub siab-targeted RNA kho.
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Fmoc-Gly-Gly-OH
Fmoc-Gly-Gly-OH yog ib qho dipeptide siv los ua lub tsev thaiv hauv cov txheej txheem peptide synthesis (SPPS). Nws nta ob glycine residues thiab Fmoc-tiv thaiv N-terminus, tso cai rau kev tswj peptide saw elongation. Vim glycine qhov me me thiab qhov yooj yim, qhov dipeptide no feem ntau tau kawm nyob rau hauv cov ntsiab lus ntawm peptide caj qaum dynamics, linker tsim, thiab cov qauv qauv hauv peptides thiab cov proteins.
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Fmoc-Thr(tBu)-Ph-OH
Fmoc-Thr(tBu)-Phe-OH yog ib lub tsev thaiv dipeptide feem ntau siv hauv cov khoom siv peptide synthesis (SPPS). Fmoc (9-fluorenylmethyloxycarbonyl) pawg tiv thaiv N-terminus, thaum pawg tBu (tert-butyl) tiv thaiv hydroxyl sab saw ntawm threonine. Qhov kev tiv thaiv dipeptide no tau kawm rau nws lub luag haujlwm hauv kev ua kom muaj txiaj ntsig zoo ntawm peptide elongation, txo cov racemization, thiab ua qauv qhia cov qauv tshwj xeeb hauv cov qauv protein thiab kev kawm sib cuam tshuam.
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AEEA-UA
AEEA-AEEA yog hydrophilic, hloov tau yooj yim spacer feem ntau siv nyob rau hauv peptide thiab tshuaj conjugation kev tshawb fawb. Nws muaj ob chav ethylene glycol-based units, ua rau nws muaj txiaj ntsig zoo rau kev kawm txog qhov cuam tshuam ntawm qhov txuas txuas ntev thiab yoog raws ntawm kev sib cuam tshuam ntawm molecular, solubility, thiab lom lom. Cov kws tshawb fawb feem ntau siv AEEA cov chav ntsuas los ntsuas seb cov spacers cuam tshuam li cas ntawm cov tshuaj tiv thaiv kab mob sib txuas (ADCs), peptide-drug conjugates, thiab lwm yam bioconjugates.
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![Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH](https://cdn.globalso.com/gentolexgroup/Glepaglutide10-300x300.png)
Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH
Cov tshuaj no yog ib qho kev tiv thaiv, ua haujlwm tau zoo lysine derivative siv hauv peptide synthesis thiab tshuaj conjugate txoj kev loj hlob. Nws nta ib pab pawg Fmoc rau N-terminal kev tiv thaiv, thiab kev hloov pauv ntawm cov saw txuas nrog Eic (OtBu) (eicosanoic acid derivative), γ-glutamic acid (γ-Glu), thiab AEEA (aminoethoxyethoxyacetate). Cov khoom no yog tsim los kawm txog cov teebmeem lipidation, spacer chemistry, thiab tswj cov tshuaj tso tawm. Nws yog dav tshawb fawb nyob rau hauv cov ntsiab lus ntawm prodrug cov tswv yim, ADC linkers, thiab membrane-interacting peptides.
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![Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH](https://cdn.globalso.com/gentolexgroup/Glepaglutide9-300x300.png)
Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH
Cov tshuaj no yog hloov kho lysine derivative siv nyob rau hauv peptide synthesis, tshwj xeeb tshaj yog rau kev tsim lub hom phiaj los yog multifunctional peptide conjugates. Fmoc pab pawg tso cai rau kev sib xyaw ua ke ntawm Fmoc solid-phase peptide synthesis (SPPS). Cov saw hlau sab yog hloov kho nrog stearic acid derivative (Ste), γ-glutamic acid (γ-Glu), thiab ob lub AEEA (aminoethoxyethoxyacetate) txuas, uas muab hydrophobicity, nqi zog, thiab hloov tau yooj yim. Nws feem ntau tau kawm txog nws lub luag haujlwm hauv kev xa tshuaj, suav nrog tshuaj tiv thaiv kab mob-tshuaj yeeb tshuaj (ADCs) thiab cell-peptides.
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Liraglutide Anti-Diabetics rau Ntshav Qab Zib Control CAS NO.204656-20-2
Cov khoom xyaw nquag:Liraglutide (analog ntawm tib neeg glucagon-zoo li peptide-1 (GLP-1) ua los ntawm cov poov xab los ntawm kev siv tshuab genetic recombination).
Lub npe tshuaj:Arg34Lys26-(N-ε-(γ-Glu(N-α-hexadecanoyl)))-GLP-1[7-37]
Lwm cov khoom xyaw:Disodium Hydrogen Phosphate Dihydrate, Propylene Glycol, Hydrochloric Acid thiab / los yog Sodium Hydroxide (raws li pH Adjusters nkaus xwb), Phenol, thiab dej rau txhaj.
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Leuprorelin Acetate tswj kev zais cia ntawm Gonadal Hormones
Lub npe: Leuprorelin
CAS Nr .: 53714-56-0
Cov mis mos molecular: C59H84N16O12
Molecular Luj: 1209.4
EINECS Tus lej: 633-395-9
Kev sib hloov tshwj xeeb: D25 -31.7 ° (c = 1 hauv 1% acetic acid)
Qhov ceev: 1.44 ± 0.1 g / cm3 (Predicted)
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Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH
Boc-His(Trt)-Aib-Gln(Trt)-Gly-OHyog ib qho kev tiv thaiv tetrapeptide siv nyob rau hauv peptide synthesis thiab kev tshawb fawb ntawm cov qauv. Cov pab pawg Boc (tert-butyloxycarbonyl) tiv thaiv N-terminus, thaum Trt (trityl) pawg tiv thaiv sab chains ntawm histidine thiab glutamine los tiv thaiv kev tsis haum xeeb. Lub xub ntiag ntawm Aib (α-aminoisobutyric acid) txhawb nqa helical conformations thiab txhim kho peptide stability. Cov peptide no muaj txiaj ntsig zoo rau kev tshawb nrhiav peptide folding, ruaj khov, thiab ua ib qho chaw rau kev tsim cov tshuaj lom neeg peptides.
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PEB-157
BPC-157 API txais cov txheej txheem sib xyaw ua ke (SPPS):
Siab purity: ≥99% (HPLC kuaj pom)
Tsawg impurity residue, tsis muaj endotoxin, tsis muaj kuab paug hnyav hlau
Batch stability, muaj zog repeatability, txhawb kev txhaj tshuaj theem siv
Txhawb gram thiab kilogram qib mov kom tau raws li qhov xav tau ntawm ntau theem ntawm R & D mus rau industrialization.