Cov khoom xyaw tshuaj
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Fmoc-Lys(Pal-Glu-OtBu)-OH
Fmoc-Lys(Pal-Glu-OtBu)-OH yog ib qho tshwj xeeb lipidated amino acid tsev thaiv tsim rau peptide-lipid conjugation. Nws nta Fmoc-tiv thaiv lysine nrog lub palmitoyl-glutamate sab saw, txhim kho daim nyias nyias affinity thiab bioavailability.
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Fmoc-His-Aib-OH
Fmoc-His-Aib-OH yog dipeptide tsev thaiv siv nyob rau hauv peptide synthesis, combining Fmoc-tiv thaiv histidine thiab Aib (α-aminoisobutyric acid). Aib qhia txog conformational rigidity, ua rau nws muaj nuj nqis rau tsim helical thiab ruaj khov peptides.
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Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH
Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH yog ib qho kev tiv thaiv tetrapeptide fragment siv nyob rau hauv peptide synthesis thiab kev tsim tshuaj. Nws muaj cov pab pawg tiv thaiv kev ua haujlwm rau kev sib txuas ua ke thiab nta Aib (α-aminoisobutyric acid) los txhim kho helix stability thiab conformational rigidity.
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Ste-γ-Glu-AEEA-AEEA-OSU
Ste-γ-Glu-AEEA-AEEA-OSU yog ib qho hluavtaws lipidated linker molecule tsim los rau kev xa tshuaj thiab tshuaj tiv thaiv kab mob-tshuaj conjugates (ADCs). Nws nta stearoyl (Ste) hydrophobic tail, γ-glutamyl lub hom phiaj motif, AEEA spacers rau qhov yooj, thiab OSu (NHS ester) pab pawg kom muaj txiaj ntsig zoo.
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Fmoc-Ile-αMeLeu-Leu-OH
Fmoc-Ile-αMeLeu-Leu-OH yog cov khoom siv hluav taws xob tiv thaiv tripeptide lub tsev thaiv uas muaj α-methylated leucine, feem ntau siv hauv peptide tshuaj tsim los txhim kho metabolic stability thiab receptor selectivity.
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Dodecyl Phosphocholine (DPC)
Dodecyl Phosphocholine (DPC) yog ib qho khoom siv zwitterionic detergent siv dav hauv kev tshawb fawb membrane protein thiab cov txheej txheem biology, tshwj xeeb tshaj yog nyob rau hauv NMR spectroscopy thiab crystallography.
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Donidalorsen
Donidalorsen API yog ib qho antisense oligonucleotide (ASO) nyob rau hauv kev tshawb nrhiav rau kev kho mob ntawm hereditary angioedema (HAE) thiab lwm yam mob. Nws yog kawm nyob rau hauv cov ntsiab lus ntawm RNA-targeted kev kho mob, aiming kom txo tau cov kev qhia ntawmntshav plasma prekallikrein(KLKB1 mRNA). Cov kws tshawb fawb siv Donidalorsen los tshawb nrhiav cov tshuaj gene silencing mechanisms, koob tshuaj raws li pharmacokinetics, thiab kev tswj mus sij hawm ntev ntawm bradykinin-mediated o.
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Fitusiran
Fitusiran API yog ib qho hluavtaws me me cuam tshuam RNA (siRNA) tau tshawb xyuas feem ntau hauv thaj tsam ntawm hemophilia thiab coagulation disorders. Nws aims lubAntithrombin (AT lossis SERPINC1)gene nyob rau hauv lub siab kom txo tau cov tshuaj antithrombin. Cov kws tshawb fawb siv Fitusiran los tshawb txog RNA cuam tshuam (RNAi) cov txheej txheem, lub siab tshwj xeeb ntawm cov gene silencing, thiab cov tswv yim kho tshiab rau rebalancing coagulation hauv cov neeg mob hemophilia A thiab B, nrog lossis tsis muaj inhibitors.
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Givosiran
Givosiran API yog ib qho hluavtaws me me cuam tshuam RNA (siRNA) tau kawm rau kev kho mob ntawm tus mob hepatic porphyria (AHP). Nws tshwj xeeb tsom rau covALAS 1noob (aminolevulinic acid synthase 1), uas yog koom nrog hauv heme biosynthesis txoj kev. Cov kws tshawb fawb siv Givosiran los tshawb xyuas RNA cuam tshuam (RNAi)-raws li kev kho mob, lub siab-targeted gene silencing, thiab kev hloov pauv ntawm cov txheej txheem metabolic koom nrog porphyria thiab cuam tshuam txog caj ces.
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Plozasiran
Plozasiran API yog ib qho hluavtaws me me cuam tshuam RNA (siRNA) tsim los rau kev kho mob hypertriglyceridemia thiab cuam tshuam txog cov hlab plawv thiab cov kab mob metabolic. Nws aims lubAPOC 3noob, uas encodes apolipoprotein C-III, ib tug tseem ceeb regulator ntawm triglyceride metabolism. Hauv kev tshawb fawb, Plozasiran yog siv los kawm RNAi-raws li lipid-txo cov tswv yim, gene-silencing tshwj xeeb, thiab kev kho mob ntev rau cov xwm txheej xws li tsev neeg chylomicronemia syndrome (FCS) thiab sib xyaw dyslipidemia.
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Zilebesiran
Zilebesiran API yog ib qho kev tshawb nrhiav me me cuam tshuam RNA (siRNA) tsim rau kev kho mob ntshav siab. Nws aims lubAGTgene, uas encodes angiotensinogen-ib qho tseem ceeb ntawm renin-angiotensin-aldosterone system (RAAS). Hauv kev tshawb fawb, Zilebesiran yog siv los kawm gene silencing txoj hauv kev rau kev tswj ntshav siab mus ntev, RNAi kev xa khoom thev naus laus zis, thiab lub luag haujlwm dav dav ntawm RAAS txoj hauv kev hauv cov kab mob plawv thiab lub raum.
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Caspofungin rau Antifungal Kab Mob
Lub npe: Caspofungin
CAS Nr .: 162808-62-0
Cov mis mos molecular: C52H88N10O15
Molecular Luj: 1093.31
EINECS Xov Tooj: 1806241-263-5
Kub taw tes: 1408.1 ± 65.0 ° C (Predicted)
Qhov ceev: 1.36 ± 0.1 g / cm3 (Predicted)
Acidity coefficient: (pKa) 9.86 ± 0.26 (Predicted)