ORListat 96829-58-2 Txo kev nqus ntawm cov rog rogtary rog, ua rau muaj kev poob phaus
Khoom Qhia Qhia
| Lub npe | Tus yeeb yaj kiab |
| Tus lej | 96829-58-2 |
| Molecular Cov Qauv | C29H53No5 |
| Molecular hnyav | 495.73 |
| Einecs tooj | 639-755-1 |
| Melting taw tes | <50 ° C |
| Ceev | 0.976 ± 0.0PG / CM3 (kwv yees) |
| Chaw Cia Khoom | 2-8 ° C |
| Puab | Hmoov |
| Xim | Xim dawb |
| Acidity Coefficient | (PMA) 14.59 ± 0.23 (kwv yees) |
Txhais lus hais tias
(S) -2-formellamino-4-Methyl-Pentanyicacid (s) -1 - [(2-oxo-2-oxo-2-oxo-2-oxo-4-0647; (-) Ormyl-L-Leucine (1s) -1 - [[(2
Pharmacological effect
Cov Khoom Siv
White crystalline powder, almost insoluble in water, easily soluble in chloroform, extremely soluble in methanol and ethanol, easy to pyrolyze, melting point is 40℃～42℃. Nws molecule yog lub diastereomer muaj plaub chairal chaw, ntawm nthwv dej 529nm, nws ethanol daws muaj kev sib hloov kho qhov muag tsis zoo.
Hom kev ua
Orlistat yog kev ua yeeb yam ntev thiab muaj zog tshwj xeeb Lipase inhiboritor, uas intactivates daim ntawv cog lus uas muaj cov kab tsib ntawm lub plab thiab txoj hnyuv. Inactivated enzymes tsis tuaj yeem tsoo cov rog hauv cov zaub mov ua kom muaj rog thiab tshuaj lom neeg uas tuaj yeem nqus tau cov rog thiab txo qhov hnyav. Tsis tas li ntawd, qee cov kev tshawb fawb tau pom tias kev tshawb fawb txoj hnyuv los cuam tshuam ntawm cov roj choleterol los ntawm kev tsis muaj protein 1 (niemann-pickC1-zoo li1, NPC1L1).
Kev taw qhia
Cov khoom lag luam no ua ke nrog cov khoom noj muaj me me yog qhia rau cov neeg rog dhau los, suav nrog cov neeg muaj kev pheej hmoo ntawm kev rog. Cov khoom no tau siv lub cev tswj qhov hnyav (phaus poob, kev txiav txim siab hnyav thiab tiv thaiv ntawm kev rov ua haujlwm). Kev noj cov orlistat tuaj yeem txo cov rog ntsig txog kev pheej hmoo, suav nrog hyperchatenchemia, hypertension, thiab cov roj teeb txo cov ntsiab lus.
Cov Tshuaj Sib Tham
Tuaj yeem txo cov vitamins A, D thiab E. Nws tuaj yeem tso ntxiv nrog cov khoom no tib lub sijhawm. Yog tias koj tau npaj npaj muaj cov vitamins A, D thiab E (xws li muaj qee cov multivitamins), koj yuav tsum siv cov khoom lag luam no 2 teev tom qab noj cov khoom no lossis sijhawm thaum mus pw. Cov neeg muaj cov ntshav qab zib hom 2 yuav tau txo cov koob tshuaj hypoglycemic endents (piv txwv li, sulfonyhluras). Co-Administration nrog Cyclosporine tuaj yeem ua rau muaj kev txo qis hauv cov ntshav dav ntawm cov tom kawg. Kev siv cov amiodarone yuav ua rau muaj kev nqus cov tom kawg thiab txo kev ua tau zoo.
