Orlistat 96829-58-2 Txo kev nqus ntawm Sietary Fat, Ua rau poob phaus
Product Detail
| Lub npe | Orlistat |
| CAS nr | 96829-58-2 |
| Cov mis mos molecular | C29H53 NPO 5 |
| Molecular hnyav | 495.73 ib |
| EINECS Number | 639-755-1 ib |
| Melting Point | <50 ° C |
| Qhov ntom | 0.976 ± 0.06g / cm3 (Kev kwv yees) |
| Kev cia khoom | 2-8 ° C |
| Daim ntawv | Hmoov |
| Xim | Dawb |
| Acidity coefficient | (pKa) 14.59 ± 0.23 (Predicted) |
Synonyms
(S)-2-FORMYLAMINO-4-METHYL-PENTANOICACID(S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]-DODECYLESTER;RO-18-0647;(-)-TetraHYL; ORMYL-L-LEUCINE(1S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]DODECYLESTER; Orlistat (synthetase/compound); Orlistat (synthesis); Orlistat (FerMentation)
Pharmacological nyhuv
Cov khoom
Dawb crystalline hmoov, yuav luag insoluble nyob rau hauv dej, yooj yim soluble nyob rau hauv chloroform, heev soluble nyob rau hauv methanol thiab ethanol, yooj yim rau pyrolyze, melting point yog 40 ℃ ~ 42 ℃. Nws cov molecule yog ib tug diastereomer uas muaj plaub chiral chaw, ntawm ib tug wavelength ntawm 529nm, nws cov tshuaj ethanol muaj tsis zoo kho qhov muag rotation.
Hom Kev Ua Haujlwm
Orlistat yog ib qho kev ua yeeb yam ntev thiab muaj zog tshwj xeeb hauv plab hnyuv lipase inhibitor, uas ua rau ob lub enzymes saum toj no los ntawm kev tsim cov ntawv cog lus nrog cov khoom siv serine ntawm lipase hauv plab thiab cov hnyuv. Inactivated enzymes tsis tuaj yeem zom cov rog hauv cov zaub mov mus rau hauv cov roj fatty acids dawb thiab Chemicalbook glycerol uas tuaj yeem nqus tau los ntawm lub cev, yog li txo cov rog thiab txo qhov hnyav. Tsis tas li ntawd, qee qhov kev tshawb fawb tau pom tias orlistat inhibits plab hnyuv nqus ntawm cov cholesterol los ntawm inhibiting niemann-pick C1-zoo li protein 1 (niemann-pickC1-like1, NPC1L1).
Cov lus qhia
Cov khoom no ua ke nrog kev noj zaub mov me me hypocaloric yog qhia rau kev kho mob ntev ntawm cov neeg rog thiab rog rog, suav nrog cov neeg uas muaj kev pheej hmoo cuam tshuam nrog kev rog. Cov khoom no muaj kev tswj qhov hnyav mus sij hawm ntev (qhov hnyav poob, kev kho qhov hnyav thiab kev tiv thaiv rov qab) kev ua tau zoo. Kev noj cov tshuaj orlistat tuaj yeem txo qhov kev pheej hmoo ntawm kev rog rog thiab qhov tshwm sim ntawm lwm cov kab mob rog rog, suav nrog hypercholesterolemia, ntshav qab zib hom 2, tsis muaj qabzib siab ntev, hyperinsulinemia, kub siab, thiab txo cov rog hauv lub cev.
Tshuaj sib cuam tshuam
Yuav txo tau qhov nqus ntawm cov vitamins A, D thiab E. Nws tuaj yeem ntxiv nrog cov khoom no tib lub sijhawm. Yog tias koj tab tom noj cov tshuaj uas muaj cov vitamins A, D thiab E (xws li ib co multivitamins), koj yuav tsum noj cov khoom no 2 teev tom qab noj cov khoom no lossis thaum mus pw. Cov neeg mob ntshav qab zib hom 2 yuav tsum tau txo cov koob tshuaj ntawm qhov ncauj hypoglycemic agents (xws li sulfonylureas). Kev tswj hwm nrog cyclosporine tuaj yeem ua rau txo qis hauv plasma concentrations tom kawg. Kev siv cov amiodarone sib xyaw ua ke tuaj yeem ua rau txo qis kev nqus ntawm qhov kawg thiab txo qhov ua tau zoo.
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