Ipamorelin

Ipamorelin API

Ipamorelin yog ib qho hluavtaws pentapeptide loj hlob hormone tso tawm peptide (GHRP) uas muaj tsib amino acids (Aib-His-D-2-Nal-D-Phe-Lys-NH₂). Nws yog ib qho kev xaiv GHSR-1a agonist nrog lub peev xwm los txhawb kev loj hlob hormone (GH) secretion nrog siab tshwj xeeb. Piv nrog rau GHRPs ua ntej (xws li GHRP-2 thiab GHRP-6), Ipamorelin qhia tau hais tias xaiv tau zoo dua, kev nyab xeeb thiab kev ruaj ntseg tshuaj tsis muaj kev cuam tshuam rau qib ntawm lwm cov tshuaj hormones xws li cortisol, prolactin lossis ACTH.

Raws li cov peptide API zoo heev, Ipamorelin yog tam sim no tau siv dav hauv kev tshawb fawb los tiv thaiv kev laus, kho kev ua kis las, kev cuam tshuam pob txha, kev rov ua haujlwm tom qab thiab kev tswj hwm kev ua haujlwm hauv metabolic.

Kev tshawb fawb thiab Mechanism of Action

Ipamorelin txhawb kev tso tawm ntawm endogenous txoj kev loj hlob hormone (GH) los ntawm lub anterior pituitary los ntawm kev xaiv activating lub loj hlob hormone secretion receptor (GHSR-1a) thiab ua raws li qhov kev txiav txim ntawm ghrelin. Nws lub ntsiab pharmacological mechanisms muaj xws li:
1. Txhawb GH secretion
Ipamorelin xaiv tau zoo siab rau GHSR-1a, ua rau lub caj pas pituitary tso GH yam tsis muaj kev cuam tshuam rau ACTH lossis cortisol qib, thiab muaj kev nyab xeeb zoo dua ntawm endocrine.
2. Txhim kho cov protein synthesis thiab kho cell
Los ntawm kev nce qib IGF-1, nws txhawb nqa cov leeg ntawm tes anabolism, txhim kho cov ntaub so ntswg thiab rov tsim dua tshiab, thiab tsim nyog rau kev kho mob, phais rov qab thiab kho cov leeg nqaij atrophy.
3. Txhim kho cov metabolism thiab faib cov rog
GH muaj cov txiaj ntsig ntawm kev rog rog thiab txhim kho insulin rhiab heev. Ipamorelin tuaj yeem pab tswj cov txheej txheem metabolic thiab siv hauv kev tshawb fawb txog metabolic syndrome thiab kev rog rog.
4. Txhim kho pob txha ceev thiab tiv thaiv kev laus
GH / IGF-1 axis tuaj yeem txhawb cov pob txha tsim thiab mineralization. Ipamorelin qhia cov lus cog tseg hauv kev tiv thaiv kab mob osteoporosis, pob txha rov ua haujlwm thiab tiv thaiv kev laus.
5. Txhim kho circadian atherosclerosis thiab pw tsaug zog zoo
GH tso tawm feem ntau yog nrog los ntawm kev pw tsaug zog. Cov kev tshawb fawb tau pom tias Ipamorelin tuaj yeem txhim kho kev pw tsaug zog tsis ncaj thiab txhim kho lub cev rov qab muaj peev xwm.
Preclinical kev tshawb fawb thiab kev txheeb xyuas kev ua tau zoo

Txawm hais tias tseem nyob rau theem preclinical/thaum ntxov, Ipamorelin tau qhia txog kev nyab xeeb thiab kev ua tau zoo hauv tsiaj thiab qee qhov kev tshawb fawb tib neeg:

GH qib tau nce ntxiv (nce siab hauv 30 feeb, kav ntev li ob peb teev)

Tsis muaj qhov pom tseeb pro-cortisol lossis pro-ACTH cuam tshuam, cov teebmeem endocrine yog tswj tau ntau dua

Txhim kho cov leeg nqaij thiab lub zog (tshwj xeeb tshaj yog cov qauv tsiaj laus)

Txhim kho kev rov qab ua haujlwm tom qab thiab kho cov ntaub so ntswg ceev

Nce qib IGF-1 pab kho cell thiab cov lus teb antioxidant

Tsis tas li ntawd, Ipamorelin ua ke nrog lwm yam GHRH mimetics (xws li CJC-1295) hauv qee qhov kev tshawb fawb pom tias muaj kev sib koom ua ke, ntxiv dag zog rau cov mem tes tso tawm GH.
API ntau lawm thiab kev ruaj ntseg zoo

Lub Ipamorelin API muab los ntawm peb Gentolex Group yog npaj siv high-standard ** cov txheej txheem peptide synthesis (SPPS) **, thiab yog nruj me ntsis purified thiab zoo kuaj, haum rau kev tshawb fawb thiab kev loj hlob thiab thaum ntxov pipeline siv ntawm cov tuam txhab tshuaj.

Cov khoom nta muaj xws li:

Purity ≥99% (HPLC xeem)
Tsis muaj endotoxin, tsis tshua muaj kuab lom, tsis muaj hlau ion paug
Muab tag nrho cov ntaub ntawv zoo: COA, daim ntawv qhia kev ruaj ntseg, kev tsom xam impurity spectrum, thiab lwm yam.
Customizable gram-level ~ kilogram-level mov