Ibtamoren Mesylate nce lub cev hnyav dua, ntshav siab-pheeb-1 thiab GH theem
Khoom Qhia Qhia
| Lub npe | Ibutamoren Mesylate |
| Tus lej | 159752-10-0 |
| Molecular Cov Qauv | C28h40n4o8o8s2 |
| Molecular hnyav | 624.77 |
| Einecs tooj | 1308068-626-2 |
| Melting taw tes | 164-170 ° C |
| So | H2O: Soluble5Mg / ml, ntshiab |
| Chaw Cia Khoom | 2-8 ° C |
| Puab | Hmoov |
| Xim | Dawb rau beige |
| Yam ntim | PE hnab + Aluminium Hnab |
Txhais lus hais tias
Mk-677; 2-amino-n - [(1,2-aws-ugo-aws noj; mk677 (ibtamorenmesylate); MK-677; CRCRENDO; MK0677; MK067; MK677; MK677; c S-1402; MK677MKMK677IBUTAMOREN; MK677MUTAMOREN; WHOHEHE_LOHE_LUCY (AT) 163.com; MK677, MK677
Pharmacological effect
Kev piav txog
Ibroholen Mesylate yog ib qho tshuaj uas ua raws li muaj zog, orally muaj kev loj hlob ntawm cov tshuaj hwj gh rau kev txhawb nqa cov tshuaj haultous.
Rooj mov
IBramolen mesylate tau pom tias muaj cov kev tso tawm ntau ntxiv thiab cov tshuaj tiv thaiv ntshav ntxiv suav nrog GH thiab insulin-xws li tsis cuam tshuam rau Cortisol qib. Cov kev pabcuam muaj peev xwm tam sim no nyob rau hauv cov tshuaj hormones no, xws li nyob rau hauv cov menyuam yaus lossis cov neeg laus cov pob txha tsis muaj zog, ua rau muaj kev kho mob ntxhia thiab cov kev kho mob muaj txiaj ntsig rau cov neeg laus tsis zoo. Nws tseem yog hloov cov metabolism ntawm lub cev rog, yog li nws yuav muaj daim ntawv thov hauv kev rog rog.
Hauv kev tshawb fawb Vivo
Ibtamoren Mesylate (5 mg / kg / hnub) ua rau lub cev tseem ceeb nce thiab nce cov ntshav-1 thiab gh qib hauv dev. Ibtamoren mesylate ua rau tsis muaj qhov nce ntxiv hauv CSF IGF-1 lossis qib siab rau hnub 7 lossis 15 ntawm kev kawm. Pretreating nas nrog gh blockation ntawm cov neurons no los ntawm ibtamoren mesylate (50 μg, IP). Hauv cov nas khob, ob qho tib si Gh thiab Octreotide tsis ua rau inhibit ibtamoren mesylate ua kom muaj arcuate neurons. Choj thawj coj ntawm MK-0677 muaj feem cuam tshuam nrog qhov tseem ceeb nce hauv GH thiab IGF-I qib uas tau khaws cia rau kev kho mob. Lub GH Profile nram qab no MK-0677 thawj coj yog muaj episodic nce siab tshaj tswj. MK-0677 nce siab dua peak gh ntau dua tom qab kev tswj hwm qhov ncauj. MK-0677 yog ib qho muaj zog GH Secretagogue uas tsim ib qho tam sim ntawd, loj, ntev ntev nce hauv GH qib thaum tswj hwm thiab IV
