Fmoc-Thr(tBu)-Ph-OH

Fmoc-Thr(tBu)-Ph-OH

Daim ntawv thov tshawb fawb:
Fmoc-Thr(tBu)-Phe-OH yog ib lub tsev thaiv dipeptide feem ntau siv hauv cov khoom siv peptide synthesis (SPPS). Fmoc (9-fluorenylmethyloxycarbonyl) pawg tiv thaiv N-terminus, thaum pawg tBu (tert-butyl) tiv thaiv hydroxyl sab saw ntawm threonine. Qhov kev tiv thaiv dipeptide no tau kawm rau nws lub luag haujlwm hauv kev ua kom muaj txiaj ntsig zoo ntawm peptide elongation, txo cov racemization, thiab ua qauv qhia cov qauv tshwj xeeb hauv cov qauv protein thiab kev kawm sib cuam tshuam.

Muaj nuj nqi:
Fmoc-Thr(tBu)-Phe-OH ua haujlwm ua ntej rau kev sib txuas cov peptides uas suav nrog threonine thiab phenylalanine residues, uas yog ib qho tseem ceeb rau kev tsim hydrogen bonds thiab hydrophobic kev sib cuam tshuam. Lub threonine sab saw pab txhawb polarity thiab muaj peev xwm phosphorylation qhov chaw, thaum phenylalanine ntxiv aromatic cwj pwm thiab cov qauv stability. Qhov kev sib xyaw ua ke no muaj txiaj ntsig zoo hauv kev tsim peptides rau kev soj ntsuam lom neeg, kev tshawb fawb txog kev sib txuas, thiab kev siv tshuaj tshawb nrhiav.