Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH

Fmoc-L-Lys[Ste(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH

Daim ntawv thov tshawb fawb:
Cov tshuaj no yog hloov kho lysine derivative siv nyob rau hauv peptide synthesis, tshwj xeeb tshaj yog rau kev tsim lub hom phiaj los yog multifunctional peptide conjugates. Fmoc pab pawg tso cai rau kev sib xyaw ua ke ntawm Fmoc solid-phase peptide synthesis (SPPS). Cov saw hlau sab yog hloov kho nrog stearic acid derivative (Ste), γ-glutamic acid (γ-Glu), thiab ob lub AEEA (aminoethoxyethoxyacetate) txuas, uas muab hydrophobicity, nqi zog, thiab hloov tau yooj yim. Nws feem ntau tau kawm txog nws lub luag haujlwm hauv kev xa tshuaj, suav nrog tshuaj tiv thaiv kab mob-tshuaj yeeb tshuaj (ADCs) thiab cell-peptides.

Muaj nuj nqi:
Fmoc-L-Lys[Ste(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH ua haujlwm raws li lub tsev thaiv kev tsim cov kab ntev lipidated peptides lossis cov tshuaj txuas txuas ntxiv. Cov stearic acid txhim kho cov membrane affinity, γ-Glu txhim kho kev ruaj ntseg thiab enzymatic tsis kam, thiab AEEA linkers muab solubility thiab cov qauv yooj yim. Ua ke, cov yam ntxwv no ua rau cov khoom muaj txiaj ntsig zoo hauv kev tsim cov peptides rau kev txhim kho bioavailability, tswj kev tso tawm, thiab cov phiaj xwm xa khoom.