Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH

Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH

Daim ntawv thov tshawb fawb:
Cov tshuaj no yog ib qho kev tiv thaiv, ua haujlwm tau zoo lysine derivative siv hauv peptide synthesis thiab tshuaj conjugate txoj kev loj hlob. Nws nta ib pab pawg Fmoc rau N-terminal kev tiv thaiv, thiab kev hloov pauv ntawm cov saw txuas nrog Eic (OtBu) (eicosanoic acid derivative), γ-glutamic acid (γ-Glu), thiab AEEA (aminoethoxyethoxyacetate). Cov khoom no yog tsim los kawm txog cov teebmeem lipidation, spacer chemistry, thiab tswj cov tshuaj tso tawm. Nws yog dav tshawb fawb nyob rau hauv cov ntsiab lus ntawm prodrug cov tswv yim, ADC linkers, thiab membrane-interacting peptides.

Muaj nuj nqi:
Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH ua lub tsev thaiv rau kev sib txuas lipid-hloov peptides lossis cov tshuab xa tshuaj. Eic moiety txhim kho lipophilicity thiab membrane khi; γ-Glu ntxiv enzymatic stability thiab lub hom phiaj muaj peev xwm; thiab AEEA ua raws li qhov hloov tau yooj yim hydrophilic linker. Ua ke, lawv ua kom muaj kev tsim kho ntawm peptides nrog kev txhim kho cellular uptake, txuas ntxiv ib nrab-lub neej, thiab qhov chaw tshwj xeeb xa khoom.