CJC-1295

CJC-1295 API

CJC-1295yog ib qho hluavtaws, tetrasubstituted peptide analogue ntawmKev loj hlob hormone tso tawm hormone (GHRH), tsim lostxhawb nqa thiab txhawb nqa kev tso tawm ntawm endogenous loj hlob hormone (GH). Tsis zoo li haiv neeg GHRH, uas muaj lub neej luv luv, CJC-1295 suav nrogDrug Affinity Complex (DAC) technology, cia nws khi covalently rau albumin hauv cov hlab ntsha thiabncua nws cov roj ntsha ib nrab-lub neej mus rau ntau tshaj 8 hnub. Qhov kev tsim kho tshiab no ua rau CJC-1295 aKev ua haujlwm ntev GHRH analoguenrog lub peev xwm tseem ceeb hauvKev tiv thaiv kev laus, kev loj hlob tsis muaj zog, kev tswj cov metabolism, cov leeg tsis muaj zog, thiab cov tshuaj regenerative.

Mechanism ntawm Action

CJC-1295 ua haujlwm ntawmGHRH receptornyob rau ntawm somatotropic hlwb nyob rau hauv lub anterior pituitary caj pas. Nws txoj haujlwm lom neeg ua raws li haiv neeg GHRH, tab sis nrog kev ncua ntev ib nrab-lub neej vim DAC hloov kho. Qhov kev txiav txim siab txhawb nqa no ua rauruaj khov pulsatile tso tawm ntawm GHthiab nce ntau lawm ntawmCov tshuaj insulin zoo li kev loj hlob 1 (IGF-1).

Cov txheej txheem tseem ceeb muaj xws li:

• Stimulation ntawm endogenous GH secretion

• Kev nce siab ntev ntawm IGF-1 qib, txhawb cov teebmeem anabolic

• Tsis muaj qhov tseem ceeb desensitizationlos yog downregulation nrog kev siv tas li

• Txhim kho lipolysis, protein synthesis, thiab cellular regeneration

Los ntawm kev ua rau lub cev tus kheej GH thiab IGF-1 txoj hauv kev, CJC-1295 zam ntau qhov teeb meem cuam tshuam nrog exogenous GH therapy, xws li receptor desensitization thiab kev txhawj xeeb txog kev nyab xeeb.

Kev Tshawb Fawb Kev Kho Mob thiab Kev Kho Mob Muaj Peev Xwm

1. Kev Loj Hlob Hormone Deficiency (GHD)

Hauv kev sim tshuaj thaum ntxov, CJC-1295 tau pom tias:

• Sustained nce nyob rau hauvGHthiabIGF-1qib mus txog rau6-10 hnubtom qab ib qho kev txhaj tshuaj

• Txotxhaj tshuaj zauspiv rau niaj hnub GHRH analogues lossis GH txhaj tshuaj

• Txhim kho cov neeg mob ua raws cai thiab hormonal stability

2. Lub cev muaj pes tsawg leeg thiab khaws cia cov leeg

Kev tshawb fawb tsiaj thiab tib neeg tau pom tias CJC-1295:

• Txhawb nqalean nqaij ncethiabtxo lub cev rog, tshwj xeeb tshaj yog visceral rog

• Txhim khonitrogen retention thiab protein synthesishauv skeletal leeg

• Tej zaum yuav pab rov qab los ntawmsarcopeniathiab cov nqaij ntshiv nqaij

3. Anti-Aging thiab Health Applications

Raws li GH thiab IGF-1 qib ib txwm poob qis nrog lub hnub nyoog, CJC-1295 tau kawm ntau ntxiv raws li kev tshawb fawb.tiv thaiv kev lausrau:

• Txhim khopw zoothiabkev cai circadian atherosclerosis

• Txhim khodaim tawv nqaij elasticity, pob txha ceev, thiabtiv thaiv kev ua haujlwm

• Txhawb nqalub zog metabolismthiabqaug zog kuj

4. Kev cai Metabolic

CJC-1295 qhia kev cog lus hauv kev hais lusinsulin tsis kamthiab metabolic syndrome los ntawm:

• Txhim khokev siv cov piam thaj

• Txhim kholipid oxidationthiabadipose cov ntaub so ntswg metabolism

• Txhawb nqatswj qhov hnyavnyob rau hauv cov neeg rog rog los yog ua ntej ntshav qab zib

API Manufacturing thiab Kev Tswj Xyuas Zoo

At Gentolex Group, pebCJC-1295 APIyog tsim los sivsolid-phase peptide synthesis (SPPS)thiab purified siv HPLC kom ua tiav siab purity thiab batch-to-batch sib xws.

Cov ntsiab lus tseem ceeb:

• Purity ≥ 99%(HPLC paub tseeb)

• Tsawg residual solvents thiab hnyav hlau

• Endotoxin-dawb, uas tsis yog-immunogenic synthesis txoj kev

• Muaj nyob rau hauvkev cai kom muaj nuj nqis: milligram mus kilogram scale

Daim ntawv thov thiab yav tom ntej muaj peev xwm

CJC-1295 yog suav tias yog ib qho kev cog lus ntev tshaj plaws GHRH analogues, nrog rau cov ntawv thov hauv:

• Kev kho mob rau cov neeg laus GH deficiency

• Kev tswj lub cev muaj pes tsawg leeg hauv kev rog thiab kev laus

• Rehabilitation los ntawm cov nqaij ntshiv los yog raug mob

• Kev ua tau zoo thiab rov ua kom rov zoo dua hauv chaw kho mob lossis kis las

• Kev txhawb nqa kev kho mob hauv kev qaug zog ntev, fibromyalgia, thiab neuroendocrine imbalance

Kev sim tshuaj tsis tu ncua tab tom tshawb nrhiav nws siv los ua lwm txoj hauv kevrecombinant GH, tshwj xeeb tshaj yog nyob rau hauv pej xeem nrhiavmuaj kev nyab xeeb, ntau dua physiological hormone modulation.