PEB-157
BPC-157 API
BPC-157 (lub npe tag nrho: Lub Cev Tiv Thaiv Lub Cev 157) yog cov khoom siv luv luv peptide uas muaj 15 amino acids, muab los ntawm cov txheej txheem ntawm cov protein tiv thaiv hauv tib neeg lub plab. Nws tau qhia txog kev kho cov ntaub so ntswg uas nws kim heev thiab muaj peev xwm tiv thaiv kab mob hauv kev sim kev tshawb fawb thiab tau txais kev pom zoo tias yog ib tus neeg muaj txiaj ntsig zoo heev rau cov neeg siv tshuaj peptide.
Raws li cov khoom siv tshuaj nquag (API), BPC-157 tau siv rau hauv ntau qhov kev tshawb fawb tshawb fawb thoob ntiaj teb los tshawb txog nws cov kev ua haujlwm lom hauv plab hnyuv, musculoskeletal system, paj hlwb, kab mob plawv thiab cov ntaub so ntswg kho, tshwj xeeb tshaj yog hauv kev kho mob thiab kev tshawb fawb los tiv thaiv.
Kev tshawb fawb thiab pharmacological mechanism ntawm kev txiav txim
BPC-157 tau kawm dav, tshwj xeeb tshaj yog nyob rau hauv vivo tsiaj sim thiab hauv vitro cell qauv, thiab nws tau pom tias muaj cov teebmeem hauv qab no:
1. Cov ntaub so ntswg regeneration thiab kev kho mob
Txhawb nqa tendon, ligament, pob txha thiab cov nqaij mos rov tsim dua tshiab, thiab tuaj yeem txhim kho angiogenesis (angiogenesis).
Ua kom lub qhov txhab zoo, kho tom qab phais thiab rov qab los ntawm cov nqaij mos raug mob, uas tau raug txheeb xyuas hauv cov qauv tsiaj xws li cov leeg pob txha, cov leeg nqaij, thiab pob txha.
2. Kev tiv thaiv kab mob hauv plab thiab kho
Hauv cov qauv xws li mob plab, enteritis, thiab colitis, BPC-157 muaj kev tiv thaiv mucosal tseem ceeb.
Nws tuaj yeem tiv thaiv plab hnyuv puas tsuaj los ntawm cov tshuaj nonsteroidal anti-inflammatory tshuaj (NSAIDs) thiab txhawb txoj hnyuv mucosal kho.
3. Anti-inflammatory thiab immunomodulatory
Nws tswj qhov sib npaug ntawm lub cev tiv thaiv kab mob los ntawm inhibiting pro-inflammatory yam (xws li TNF-α, IL-6) thiab upregulating anti-inflammatory yam.
Nws muaj peev xwm muaj txiaj ntsig zoo li kev kho mob rau cov kab mob inflammatory xws li ** mob caj dab rheumatoid thiab kab mob plab hnyuv (IBD) ** .
4. Neuroprotection thiab neuroregeneration
Hauv cov qauv tom qab tus txha caj qaum raug mob, paj hlwb contusion, thiab cerebrovascular txheej xwm, BPC-157 tuaj yeem txhawb cov paj hlwb rov tsim dua tshiab thiab txo cov paj hlwb.
Nws tuaj yeem tawm tsam cov teeb meem hauv thaj tsam neuropsychiatric xws li kev ntxhov siab, kev nyuaj siab, thiab kev haus dej cawv (kev sim theem).
5. Kev tiv thaiv kab mob plawv thiab vascular
BPC-157 tuaj yeem txhim kho vascular permeability thiab txhawb kev kho microvascular, thiab ntseeg tau tias muaj txiaj ntsig zoo rau cov kab mob xws li myocardial ischemia, venous thrombosis, thiab mob hlab ntsha.
Kev sim thiab kev tshawb fawb preclinical
Txawm hais tias BPC-157 tseem tsis tau pom zoo rau tib neeg cov tshuaj, nws tau pom hauv kev sim tsiaj:
Qhov tseem ceeb acceleration ntawm cov ntaub so ntswg kho lub sij hawm (xws li 50% acceleration ntawm tendon kho)
Tseem ceeb txo qhov tshwm sim ntawm gastric los ntshav, plab hnyuv raug mob, thiab txoj hnyuv ulcers
Txhim kho cov hlab ntsha conduction rov qab thiab txhim khu kev ua haujlwm ntawm thaj chaw innervated
Ua kom angiogenesis thiab granulation cov ntaub so ntswg tsim tus nqi
Vim yog cov txiaj ntsig no, BPC-157 tau dhau los ua ib qho tseem ceeb ntawm kev tshawb fawb tus neeg sib tw molecule hauv kev kho mob tom qab kev puas tsuaj, kev raug mob kis las, kab mob hauv plab, thiab kab mob neurodegenerative.
API ntau lawm thiab kev tswj kom zoo
BPC-157 API muab los ntawm peb pawg Gentolex tau txais cov txheej txheem sib xyaw ua ke (SPPS) thiab tsim nyob rau hauv GMP cov xwm txheej. Nws muaj cov yam ntxwv hauv qab no:
Siab purity: ≥99% (HPLC kuaj pom)
Tsawg impurity residue, tsis muaj endotoxin, tsis muaj kuab paug hnyav hlau
Batch stability, muaj zog repeatability, txhawb kev txhaj tshuaj theem siv
Txhawb gram thiab kilogram qib mov kom tau raws li qhov xav tau ntawm ntau theem ntawm R & D mus rau industrialization.
