Zilebesiran

Kev tswj hwm (API)

Daim ntawv thov tshawb fawb:
Zilebesiran API yog ib qho kev tshawb nrhiav me me cuam tshuam RNA (siRNA) tsim rau kev kho mob ntshav siab. Nws aims lubAGTgene, uas encodes angiotensinogen-ib qho tseem ceeb ntawm renin-angiotensin-aldosterone system (RAAS). Hauv kev tshawb fawb, Zilebesiran yog siv los kawm gene silencing txoj hauv kev rau kev tswj ntshav siab mus ntev, RNAi kev xa khoom thev naus laus zis, thiab lub luag haujlwm dav dav ntawm RAAS txoj hauv kev hauv cov kab mob plawv thiab lub raum.

Muaj nuj nqi:
Zilebesiran ua haujlwm los ntawm kev ntsiag toAGTmRNA nyob rau hauv daim siab, uas ua rau txo zus tau tej cov angiotensinogen. Qhov no ua rau txo qis qis hauv cov qib angiotensin II, pab txo cov ntshav siab hauv kev txhawb nqa. Raws li API, Zilebesiran ua rau muaj kev txhim kho ntawm kev ua haujlwm ntev, kev kho mob subcutaneous antihypertensive nrog lub peev xwm rau peb lub hlis twg lossis ob xyoos, muab kev ua kom zoo dua qub thiab tswj ntshav siab.