Tianeptine rau 5-ht system, sedation, anti-acetylcholine thiab cardiotoxicity rau kev nyuaj siab
Khoom Qhia Qhia
| Lub npe | Yusa |
| Tus lej | 1224690-84-9 |
| Molecular Cov Qauv | C21H27Cln2o8S2 |
| Molecular hnyav | 535.02 |
| Melting taw tes | 129-131 ° C |
| Kub taw tes | 609.2ºC nyob rau 760 MmHG |
| Kev coj dawb huv | 99% |
| Chaw ntim khoom | Kaw Hauv Qhuav, Chav Chav |
| Puab | Hmoov |
| Xim | Xim dawb |
| Yam ntim | PE hnab + Aluminium Hnab |
Txhais lus hais tias
Thm; Tianeptyhemisulfatemonohydrate (thm); Tianeptinesulfate; TianeptinesulfateInTulfate; tianeptinesulfastulate; tyceptinesulfastulate; tryptinesulcelulfate; tycptinesulcelulfate; tycptinesulcelulfate; tycptinesulcelfowder / Tian epinsulfate
Pharmacological effect
Pharmacological effect
1. Cov tshuaj tiv thaiv kev ntxhov siab ntawm cov khoom no txawv ntawm cov tsoos tsoos ib txwm muaj. Nws tuaj yeem nce ntxiv up up of 5-ht hauv synaptic cleft, tab sis muaj cov nyhuv tsis muaj zog rau ntawm 5-ht thiab na. Tej zaum yuav muaj cov nyhuv ntawm kev txhim kho 5-HT Neuronal kis. Nws tsis muaj ib qho muaj ib zaug rau cov m receptors, H1, α1 thiab α2-li cov kheej kheej.
2. Cov antidepressant ua tau zoo ntawm cov khoom no zoo ib yam li TCA, thiab kev nyab xeeb thiab thev tau zoo dua TCA (Trricyclic antidepressants). Qhov ua tau zoo ntawm cov khoom no zoo ib yam li SSRI fluoxetine.
3. Kev sim tshuaj yeeb tshuaj tau pom tias nws tuaj yeem: nce qhov tshwm sim ntawm pyramidal thiab nrawm rov qab los ntawm nws txoj haujlwm tom qab kev txwv; Nce cov reabsorption ntawm 5-hydroxyboardcine los ntawm neurons hauv cortebral cortex thiab hippocampus.
Kev Tshawb Fawb Kev Tshawb Fawb
- Mob siab, subacute thiab ntev-lub sij hawm kev sim ua ntej ntev: Tsis muaj kev hloov pauv hauv biology, nplooj siab muaj nuj nqi, pathological anatomy.
- Kev ua me nyuam yam toxicity thiab Teratogenicity Test: Teratogenicity Test: Tianeptine tsis muaj kev cuam tshuam rau kev ua me nyuam muaj peev xwm kho cov niam txiv thiab cov menyuam yaus.
- Mutagenicity xeem: Tianeptine tsis muaj cov nyhuv mutagenic.
Sab cuam
- Qhov mob ovigmic, mob plab, qhov ncauj qhuav, xeev siab, ntuav, quav tawv, txhob txwm quav tawv, zoo nkauj;
- Insomnia, tsaug zog, npau suav phem, tsis muaj zog;
- Tachycardia, ExtraYystesces, mob siab tshaj plaws;
- Kiv taub hau, mob taub hau, tsaus muag, tshee, yaug ntawm lub ntsej muag;
- Ua tsis taus pa luv, zoo li tsis sib haum hauv lub caj pas;
- Myalgia, rov mob mob, thiab lwm yam.
