Semaglutide
Semaglutide API
Semaglutide yog cov khoom siv ntev-ua yeeb yam glucagon-zoo li peptide-1 (GLP-1) receptor agonist, tsim los kho hom 2 mob ntshav qab zib mellitus thiab rog rog. Cov qauv hloov kho kom tiv thaiv cov enzymatic degradation thiab txhim kho ib nrab-lub neej, Semaglutide tso cai rau kev siv tshuaj ib zaug ib lim tiam, txhim kho cov neeg mob ua raws.
PebSemaglutide APIyog tsim los ntawm cov txheej txheem hluavtaws tag nrho, tshem tawm cov kev pheej hmoo cuam tshuam nrog cov kab ke lom neeg, xws li cov cell cell protein lossis DNA paug. Tag nrho cov txheej txheem tsim khoom tau tsim thiab siv tau raws li qhov hnyav ntawm kilogram, ua tau raws li cov kev cai nruj nruj uas tau teev tseg hauv FDA's 2021 kev taw qhia ntawm ANDA xa rau high-purity hluavtaws peptide tshuaj.
Mechanism ntawm Action
Semaglutide ua rau tib neeg GLP-1, ib qho tshuaj incretin uas ua lub luag haujlwm tseem ceeb hauv cov piam thaj metabolism. Nws ua los ntawm ntau yam kev sib koom ua ke:
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Stimulates insulin secretionnyob rau hauv ib tug glucose-dependent yam
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Txo glucagon secretion, txo cov piam thaj hauv siab
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Delays plab hnyuv, ua rau kev txhim kho postprandial glycemic tswj
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Txo qab los noj mov thiab lub zog noj, txhawb kev poob phaus
Cov txiaj ntsig kho mob
Kev tshawb fawb soj ntsuam dav dav (piv txwv li, SUSTAIN thiab STEP kev sim) tau pom tias Semaglutide:
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Qhov tseem ceeb txo qis HbA1c thiab ceev ceev plasma qabzib hauv cov neeg mob ntshav qab zib hom 2
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Txhawb kev poob phaus ntau thiab txhawb nqa hauv cov neeg rog rog lossis rog
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Txo cov kab mob plawv xws li ntshav siab thiab mob
Nrog rau qhov muaj txiaj ntsig zoo ntawm kev nyab xeeb thiab cov txiaj ntsig dav hauv metabolic, Semaglutide tau dhau los ua thawj kab GLP-1 RA hauv ntshav qab zib thiab kev kho rog rog. Peb cov API version tswj hwm cov qauv kev ntseeg siab thiab qib impurity tsawg (≤0.1% tsis paub impurities los ntawm HPLC), kom ntseeg tau cov tshuaj zoo sib xws.
