REVERSE T3 rau protein synthesis, thermoregulation, zog tsim thiab tswj
Product Detail
| Lub npe | TXOJ CAI T3 |
| CAS nr | 5817-39-0 |
| Cov mis mos molecular | C15H12I3NO4 |
| Molecular hnyav | 650.97 ib |
| Melting point | 234-238 ° C |
| Boiling point | 534.6 ± 50.0 ° C |
| Purity | 98% |
| Cia | Khaws rau hauv qhov chaw tsaus, kaw hauv qhov qhuav, Khaws rau hauv lub freezer, qis dua -20 ° C |
| Daim ntawv | Hmoov |
| Xim | Pale Beige rau Brown |
| Ntim | PE hnab + Aluminium hnab |
Synonyms
T3(3,3',5'-Triiodo-L-Thyronine);L-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-;(2S)-2-aMino-3-[4-(4-hydroxy-3,5-diiodophe) noxy)-3-iodophenyl]propanoicacid;REVERSET3;T3;LIOTHYRONIN;L-3,3',5'-TRIIODOTHYRONINE;3,3′,5′-Triiodo-L-thyronine (ReverseT3) kev daws
Pharmacological nyhuv
Kev piav qhia
Cov thyroid caj pas yog qhov loj tshaj plaws endocrine caj pas nyob rau hauv tib neeg lub cev, thiab lub ntsiab active tshuaj secreted yog tetraiodothyronine (T4) thiab triiodothyronine (T3), uas yog heev tseem ceeb rau protein synthesis, lub cev kub tswj, lub zog tsim thiab kev tswj lub luag hauj lwm. Feem ntau ntawm T3 hauv cov ntshav yog hloov los ntawm peripheral cov ntaub so ntswg deiodination, thiab ib feem me me ntawm T3 yog ncaj qha los ntawm cov thyroid thiab tso tawm rau hauv cov ntshav. Feem ntau ntawm T3 nyob rau hauv cov ntshav yog khi rau khi cov proteins, txog 90% ntawm cov uas yog khi rau thyroxine-binding globulin (TBG), tus so yog khi rau albumin, thiab ib tug tsawg heev yog khi rau thyroxine-binding prealbumin (TBPA). Cov ntsiab lus ntawm T3 hauv cov ntshav yog 1/80-1/50 ntawm T4, tab sis kev ua haujlwm lom ntawm T3 yog 5-10 npaug ntawm T4. T3 plays lub luag haujlwm tseem ceeb hauv kev txiav txim siab txog lub cev ntawm tib neeg lub cev, yog li nws tseem ceeb heev kom pom cov ntsiab lus T3 hauv cov ntshav.
Clinical tseem ceeb
Kev txiav txim siab ntawm triiodothyronine yog ib qho ntawm cov cim qhia txog kev kuaj mob hyperthyroidism. Thaum hyperthyroidism nce, nws kuj yog ib qho precursor rau rov tshwm sim ntawm hyperthyroidism. Tsis tas li ntawd, nws tseem yuav nce ntxiv thaum cev xeeb tub thiab mob siab mob siab. Hypothyroidism, goiter yooj yim, mob nephritis thiab mob ntev, kab mob siab ntev, daim siab mob siab txo qis. Serum T3 concentration qhia txog kev ua haujlwm ntawm cov thyroid caj pas ntawm cov ntaub so ntswg ib puag ncig es tsis yog lub xeev secretory ntawm cov thyroid caj pas. Kev txiav txim siab T3 tuaj yeem siv rau kev kuaj mob ntawm T3-hyperthyroidism, kev txheeb xyuas ntawm hyperthyroidism thaum ntxov thiab kev kuaj mob ntawm pseudothyrotoxicosis. Tag nrho cov ntshav ntshav T3 feem ntau ua raws li kev hloov pauv ntawm qib T4. Nws yog ib qho kev qhia rhiab rau kev kuaj mob ntawm cov thyroid ua haujlwm, tshwj xeeb tshaj yog rau kev kuaj mob ntxov. Nws yog ib qho kev kuaj mob tshwj xeeb rau T3 hyperthyroidism, tab sis nws muaj nqi me ntsis rau kev kuaj mob ntawm cov thyroid ua haujlwm. Rau cov neeg mob kho nrog cov tshuaj thyroid, nws yuav tsum tau ua ke nrog tag nrho thyroxine (TT4) thiab, yog tias tsim nyog, thyrotropin (TSH) tib lub sijhawm los pab txiav txim rau cov thyroid ua haujlwm.
