Cov khoom
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Givosiran
Givosiran API yog ib qho hluavtaws me me cuam tshuam RNA (siRNA) tau kawm rau kev kho mob ntawm tus mob hepatic porphyria (AHP). Nws tshwj xeeb tsom rau covALAS 1noob (aminolevulinic acid synthase 1), uas yog koom nrog hauv heme biosynthesis txoj kev. Cov kws tshawb fawb siv Givosiran los tshawb xyuas RNA cuam tshuam (RNAi)-raws li kev kho mob, lub siab-targeted gene silencing, thiab kev hloov pauv ntawm cov txheej txheem metabolic koom nrog porphyria thiab cuam tshuam txog caj ces.
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Pegcetacoplan
Pegcetacoplan yog ib qho pegylated cyclic peptide uas ua raws li lub hom phiaj C3 ntxiv inhibitor, tsim rau kev kho mob ntawm cov kab mob sib ntxiv xws li paroxysmal nocturnal hemoglobinuria (PNH) thiab thaj chaw atrophy (GA) hauv cov hnub nyoog ntsig txog macular degeneration.
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Plozasiran
Plozasiran API yog ib qho hluavtaws me me cuam tshuam RNA (siRNA) tsim los rau kev kho mob hypertriglyceridemia thiab cuam tshuam txog cov hlab plawv thiab cov kab mob metabolic. Nws aims lubAPOC 3noob, uas encodes apolipoprotein C-III, ib tug tseem ceeb regulator ntawm triglyceride metabolism. Hauv kev tshawb fawb, Plozasiran yog siv los kawm RNAi-raws li lipid-txo cov tswv yim, gene-silencing tshwj xeeb, thiab kev kho mob ntev rau cov xwm txheej xws li tsev neeg chylomicronemia syndrome (FCS) thiab sib xyaw dyslipidemia.
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Zilebesiran
Zilebesiran API yog ib qho kev tshawb nrhiav me me cuam tshuam RNA (siRNA) tsim rau kev kho mob ntshav siab. Nws aims lubAGTgene, uas encodes angiotensinogen-ib qho tseem ceeb ntawm renin-angiotensin-aldosterone system (RAAS). Hauv kev tshawb fawb, Zilebesiran yog siv los kawm gene silencing txoj hauv kev rau kev tswj ntshav siab mus ntev, RNAi kev xa khoom thev naus laus zis, thiab lub luag haujlwm dav dav ntawm RAAS txoj hauv kev hauv cov kab mob plawv thiab lub raum.
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Palopegteriparatide
Palopegteriparatide yog ib tug ntev-acting parathyroid hormone receptor agonist (PTH1R agonist), tsim los rau kev kho mob ntawm mob hypoparathyroidism. Nws yog ib qho pegylated analogue ntawm PTH (1-34) tsim los muab cov kev cai calcium uas ruaj khov nrog kev noj ib zaug ib lim tiam.
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GHRP-6
GHRP-6 (Growth Hormone Releasing Peptide-6) yog ib qho hluavtaws hexapeptide uas ua raws li kev loj hlob hormone secretagogue, stimulating lub cev lub ntuj tso tawm ntawm kev loj hlob hormone (GH) los ntawm activating GHSR-1a receptor.
API nta:
Purity ≥99%
Tsim los ntawm solid-phase peptide synthesis (SPPS)
Muab rau R & D thiab kev lag luam siv
GHRP-6 yog ntau yam kev tshawb fawb peptide rau kev txhawb nqa metabolic, kev tsim cov leeg nqaij, thiab kev hloov kho hormonal.
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GHRP-2
GHRP-2 (Growth Hormone Releasing Peptide-2) yog ib qho hluavtaws hexapeptide thiab muaj zog loj hlob hormone secretagogue, tsim los txhawb lub ntuj tso tawm ntawm kev loj hlob hormone (GH) los ntawm kev ua kom GHSR-1a receptor nyob rau hauv hypothalamus thiab pituitary.
API nta:
Purity ≥99%
Muaj rau R & D thiab cov khoom lag luam, nrog rau cov ntaub ntawv QC tag nrho
GHRP-2 yog ib qho tseem ceeb tshawb fawb peptide hauv kev ua haujlwm ntawm endocrinology, tshuaj kho dua tshiab, thiab kev kho hnub nyoog.
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Hexarelin
Hexarelin yog ib qho hluavtaws loj hlob hormone secretagogue peptide (GHS) thiab muaj zog GHSR-1a agonist, tsim los txhawb kev loj hlob hormone (GH) tso tawm. Nws belongs rau ghrelin mimetic tsev neeg thiab yog tsim los ntawm 6 amino acids (ib hexapeptide), muab kev txhim kho metabolic stability thiab muaj zog GH-tso tawm los piv rau cov analogs ua ntej xws li GHRP-6.
API nta:
Purity ≥ 99%
Ua los ntawm solid-phase peptide synthesis (SPPS)
GMP-zoo li cov qauv, tsis tshua muaj endotoxin thiab hnyav residues
Flexible mov: R & D rau kev lag luam nplai
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Melanotan II
API nta:
purity siab ≥ 99%
Synthesized ntawm solid-phase peptide synthesis (SPPS)
Tsawg endotoxin, tsawg residual kuab tshuaj
Muaj nyob rau hauv R & D rau kev lag luam nplai -
Melanotan 1
Melanotan 1 API yog tsim los siv cov txheej txheem peptide synthesis (SPPS) thev naus laus zis raws li kev tswj hwm zoo li GMP.
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Siab purity ≥99%
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Solid-phase peptide synthesis (SPPS)
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GMP zoo li cov qauv tsim khoom
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Cov ntaub ntawv tag nrho: COA, MSDS, cov ntaub ntawv ruaj khov
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Scalable mov: R & D mus rau qib lag luam
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MOTS-C
MOTS-C API yog tsim nyob rau hauv nruj GMP-zoo li tej yam kev mob siv cov khoom theem peptide synthesis (SPPS) technology los xyuas kom meej nws zoo, siab purity thiab siab stability rau kev tshawb fawb thiab kev siv kho mob.
Khoom nta:Purity ≥ 99% (tau lees paub los ntawm HPLC thiab LC-MS),
Tsawg endotoxin thiab residual kuab tshuaj,
Ua raws li ICH Q7 thiab GMP raws tu qauv,
Muaj peev xwm ua tiav cov khoom loj, los ntawm milligram-theem R & D batch mus rau gram-theem thiab kilogram-theem coj mus muag khoom. -
Ipamorelin
Ipamorelin API yog npaj los ntawm high-standard ** khoom theem peptide synthesis txheej txheem (SPPS) ** thiab dhau mus nruj purification thiab zoo xeem, haum rau thaum ntxov pipeline siv nyob rau hauv kev tshawb fawb thiab kev loj hlob thiab cov tuam txhab tshuaj.
Cov khoom nta muaj xws li:
Purity ≥99% (HPLC xeem)
Tsis muaj endotoxin, tsis tshua muaj kuab lom, tsis muaj hlau ion paug
Muab tag nrho cov ntaub ntawv zoo: COA, daim ntawv qhia kev ruaj ntseg, kev tsom xam impurity spectrum, thiab lwm yam.
Customizable gram-level ~ kilogram-level mov