Cov khoom
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Fmoc-Ile-αMeLeu-Leu-OH
Fmoc-Ile-αMeLeu-Leu-OH yog cov khoom siv hluav taws xob tiv thaiv tripeptide lub tsev thaiv uas muaj α-methylated leucine, feem ntau siv hauv peptide tshuaj tsim los txhim kho metabolic stability thiab receptor selectivity.
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Dodecyl Phosphocholine (DPC)
Dodecyl Phosphocholine (DPC) yog ib qho khoom siv zwitterionic detergent siv dav hauv kev tshawb fawb membrane protein thiab cov txheej txheem biology, tshwj xeeb tshaj yog nyob rau hauv NMR spectroscopy thiab crystallography.
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N-Acetylneuraminic Acid (Neu5Ac Sialic Acid)
N-Acetylneuraminic Acid (Neu5Ac), feem ntau hu ua sialic acid, yog ib txwm tshwm sim monosaccharide koom nrog hauv kev ua haujlwm tseem ceeb hauv cellular thiab tiv thaiv kab mob. Nws ua lub luag haujlwm tseem ceeb hauv kev qhia xovtooj ntawm tes, tiv thaiv kab mob, thiab kev loj hlob ntawm lub hlwb.
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Ergothioneine
Ergothioneine yog ib qho tshwm sim ntawm cov amino acid-derived antioxidant, kawm txog nws cov cytoprotective muaj zog thiab tiv thaiv kev laus. Nws yog synthesized los ntawm fungi thiab kab mob thiab accumulates nyob rau hauv cov ntaub so ntswg raug oxidative kev nyuaj siab.
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NMN
Preclinical thiab thaum ntxov tib neeg cov kev tshawb fawb qhia NMN yuav txhawb nqa lub neej ntev, lub cev muaj zog, thiab kev txawj ntse.
API nta:
Siab purity ≥99%
Pharmaceutical-qib, haum rau qhov ncauj los yog txhaj tshuaj formulations
Ua raws li GMP-zoo li tus qauv
NMN API yog qhov zoo tshaj plaws rau kev siv tshuaj tiv thaiv kev laus, kev kho mob metabolic, thiab kev tshawb fawb ntev.
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Glucagon
Glucagon yog ib qho tshuaj peptide ntuj siv los ua kev kho mob xwm txheej ceev rau kev mob ntshav qab zib mellitus hnyav thiab kawm txog nws lub luag haujlwm hauv kev tswj cov metabolism, kev poob phaus, thiab kev kuaj mob plab.
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Motixafortide
Motixafortide yog ib qho hluavtaws CXCR4 antagonist peptide tsim los txhawb cov kab mob hematopoietic qia hlwb (HSCs) rau kev hloov pauv hauv autologous thiab tseem tau kawm hauv oncology thiab immunotherapy.
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Glepaglutide
Glepaglutide yog ib qho kev ua haujlwm ntev GLP-2 analog uas tsim los rau kev kho mob plab plob tsis so tswj (SBS). Nws txhim kho txoj hnyuv nqus thiab kev loj hlob, pab cov neeg mob txo qis kev vam khom ntawm cov khoom noj khoom haus parenteral.
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Elamipretide
Elamipretide yog mitochondria-targeted tetrapeptide tsim los kho cov kab mob tshwm sim los ntawm mitochondrial dysfunction, nrog rau thawj mitochondrial myopathy, Barth syndrome, thiab lub plawv tsis ua hauj lwm.
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Donidalorsen
Donidalorsen API yog ib qho antisense oligonucleotide (ASO) nyob rau hauv kev tshawb nrhiav rau kev kho mob ntawm hereditary angioedema (HAE) thiab lwm yam mob. Nws yog kawm nyob rau hauv cov ntsiab lus ntawm RNA-targeted kev kho mob, aiming kom txo tau cov kev qhia ntawmntshav plasma prekallikrein(KLKB1 mRNA). Cov kws tshawb fawb siv Donidalorsen los tshawb nrhiav cov tshuaj gene silencing mechanisms, koob tshuaj raws li pharmacokinetics, thiab kev tswj mus sij hawm ntev ntawm bradykinin-mediated o.
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Fitusiran
Fitusiran API yog ib qho hluavtaws me me cuam tshuam RNA (siRNA) tau tshawb xyuas feem ntau hauv thaj tsam ntawm hemophilia thiab coagulation disorders. Nws aims lubAntithrombin (AT lossis SERPINC1)gene nyob rau hauv lub siab kom txo tau cov tshuaj antithrombin. Cov kws tshawb fawb siv Fitusiran los tshawb txog RNA cuam tshuam (RNAi) cov txheej txheem, lub siab tshwj xeeb ntawm cov gene silencing, thiab cov tswv yim kho tshiab rau rebalancing coagulation hauv cov neeg mob hemophilia A thiab B, nrog lossis tsis muaj inhibitors.
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Givosiran
Givosiran API yog ib qho hluavtaws me me cuam tshuam RNA (siRNA) tau kawm rau kev kho mob ntawm tus mob hepatic porphyria (AHP). Nws tshwj xeeb tsom rau covALAS 1noob (aminolevulinic acid synthase 1), uas yog koom nrog hauv heme biosynthesis txoj kev. Cov kws tshawb fawb siv Givosiran los tshawb xyuas RNA cuam tshuam (RNAi)-raws li kev kho mob, lub siab-targeted gene silencing, thiab kev hloov pauv ntawm cov txheej txheem metabolic koom nrog porphyria thiab cuam tshuam txog caj ces.