Pregabalin rau kev kho mob ntawm peripheral neuralgia thiab kev kho kom zoo ntawm cov chaw qaug dab peg hauv zos uas muaj cov duab

Pregabalin rau kev kho mob ntawm peripheral neuralgia thiab adjuvant kev kho mob ntawm cov qaug dab peg hauv zos

Cov lus piav qhia luv luv:

Melting point: 194-196 ° C

Kev sib hloov tshwj xeeb: D23 + 10.52 ° (c = 1.06inwater)

BLAIL NTAM: 274.0 ± 6.0 ° C (kwv yees)

Nrig: 0.997 ± 0.06g / CM3 (kwv yees)

Nyem taw tes: 9 ° C

Kev Cia Siab Cia: 2-8 ° C

Solubility: dej deionized: ≥10mg / ml

Daim Ntawv: Whitepowder

Acidity Coefficient: (PKA) 4.23 ± 0.10 (kwv yees)

Dej Solubility: Solubleto100mminwater

Xa email rau peb

Khoom Qhia Qhia

Khoom Ntawv

Khoom Qhia Qhia

Lub npe	Pregabalin
Tus lej	148553-50-8
Molecular Cov Qauv	C8h17No2
Molecular hnyav	159.23
Einecs tooj	604-639-1
Kub taw tes	274.0 ± 23.0 ° C
Kev coj dawb huv	98%
Chaw ntim khoom	Kaw Hauv Qhuav, Chav Chav
Puab	Hmoov
Xim	Xim dawb
Yam ntim	PE hnab + Aluminium Hnab

Txhais lus hais tias

3 (s) - (Aminomethyl) -5-MethylhexoCoic acid; (3s) -3- (aminomethyl) -5-metylinalin; Pregabalin; Pregabalin; Pregabalin; prednisolonesodiumphosphate; (r ) -Pregabalin; (s) -pregabalin

Pharmacological effect

Pharmacological effect
Pregabalin muaj kev kho mob zoo ntawm kev mob vwm. Kev tshawb fawb txog ntau yam tsiaj qaug dab peg pom tias muaj qhov tshwm sim epiliTin tau muaj peev xwm tiv thaiv kev qaug dab peg epililic, thiab nws cov koob tshuaj tiv thaiv no yog 3-10 zaug qis dua li gabapentin. Cov kev tshawb fawb tau pom tias cov qauv kev ua kom zoo nkauj thiab cov kab mob caj dab Ntshuam Stimuli. tus cwj pwm ntawm. Cov kev tshawb fawb tsiaj tau pom tias cov khoom muaj txiaj ntsig yuav muaj qhov zoo hauv kev sib xyaw nrog opioids. Pregabalin muab qhov kev xaiv tshiab rau kev kho mob ntawm neuropathic mob.

Lub tshuab
Pregabalin tuaj yeem txo cov calcium-nyob kev tso tawm ntawm qee cov neurotransmitters los ntawm kev muaj nuj nqi calcium channel muaj nuj nqi. Txawm hais tias Pregabalin yog ib qho kev ua kom muaj kev cuam tshuam ntawm inibitory Neurotransmitter γ-am benzodiazepine receded, lossis tsis hloov mus rau kev saib xyuas neured, tsis hloov pauv ntawm Gaba hauv lub Lub hlwb ntawm nas, thiab tsis muaj mob hnyav rau Gaba Uptake lossis kev ua haujlwm. Txawm li cas los xij, txoj kev tshawb no pom tias ntev ntev ntawm cov neeg neurronged rau Pregabalin nce lub ntom ntom ntawm Gaba thauj khoom thiab tus nqi ntawm kev thauj khoom Gaba ua haujlwm zoo. Pregabalin tsis thaiv sodium raws, tsis muaj kev ua si ntawm dopamine thiab tsis muaj kev cuam tshuam ntawm dopamine, serotonin, lossis norepinephrine. ingest.

Cov Tshuaj Sib Tham
1. Nws tsis yog metabolized los ntawm Cytochrome P450 system, yog li ntawd, nws tsis tshua muaj kev cuam tshuam nrog lwm cov tshuaj. Nws tsis cuam tshuam rau cov tshuaj papearoninetics ntawm cov tshuaj tiv thaiv tshuaj (xws li sodium valproate, penytoin, cov neeg tiv thaiv kab mob ntawm qhov ncauj, diuretics, thiab insulin.
2. Thaum cov khoom lag luam no tau siv ua ke nrog oxycodone, nws txoj haujlwm lees paub yuav raug txo kom tsawg thiab lub cev muaj zog kev puas tsuaj yuav tau txhim kho.
3. Nws muaj cov txiaj ntsig ntxiv nrog Lorazepam thiab ethanol.

Yav dhau los: Estradiol valerate ntxiv cov tshuaj estrogen, kho mob prostate, thiab inhibit ovulation

Tom ntej: Estradiol Cypesteate

Sau koj cov lus ntawm no thiab xa mus rau peb