Plozasiran

Plozasiran (API)

Daim ntawv thov tshawb fawb:
Plozasiran API yog ib qho hluavtaws me me cuam tshuam RNA (siRNA) tsim los rau kev kho mob hypertriglyceridemia thiab cuam tshuam txog cov hlab plawv thiab cov kab mob metabolic. Nws aims lubAPOC 3noob, uas encodes apolipoprotein C-III, ib tug tseem ceeb regulator ntawm triglyceride metabolism. Hauv kev tshawb fawb, Plozasiran yog siv los kawm RNAi-raws li lipid-txo cov tswv yim, gene-silencing tshwj xeeb, thiab kev kho mob ntev rau cov xwm txheej xws li tsev neeg chylomicronemia syndrome (FCS) thiab sib xyaw dyslipidemia.

Muaj nuj nqi:
Plozasiran ua haujlwm los ntawm kev ntsiag toAPOC 3mRNA hauv daim siab, ua rau txo qis hauv apolipoprotein qib C-III. Qhov no txhawb kev txhim kho lipolysis thiab tshem tawm triglyceride-nplua nuj lipoproteins los ntawm cov hlab ntsha. Raws li API, Plozasiran tso cai rau kev txhim kho cov kev kho mob ntev uas ua rau txo qis triglyceride ntau ntau thiab txo qhov kev pheej hmoo ntawm tus mob pancreatitis thiab cov kab mob plawv hauv cov neeg mob uas muaj mob hnyav lossis caj ces lipid.