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Dab tsi yog BPC-157

  • Lub npe tag nrho:Lub cev tiv thaiv kab mob-157, apentadecapeptide (15-amino acid peptide)Ameslikas cais los ntawm tib neeg lub plab kua txiv.

  • Amino acid theem:Gly-Glu-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, molecular hnyav ≈ 1419.55 Da.

  • Piv nrog rau ntau lwm cov peptides, BPC-157 yog qhov ruaj khov hauv dej thiab kua txiv hmab txiv ntoo, uas ua rau lub qhov ncauj lossis plab hnyuv ua tau ntau dua.

Mechanisms ntawm Action

  1. Angiogenesis / Circulatory Recovery

    • UpregulatesVEGFR-2kev nthuav qhia, txhawb kev tsim cov hlab ntsha tshiab.

    • Activates lubSrc–Caveolin-1–eNOS txoj kev, ua rau nitric oxide (NO) tso tawm, vasodilation, thiab txhim kho vascular muaj nuj nqi.

  2. Anti-inflammatory & Antioxidant

    • Downregulates pro-inflammatory cytokines xws liIL-6thiabTNF-α.

    • Txo cov pa oxygen reactive (ROS) ntau lawm, tiv thaiv cov hlwb los ntawm oxidative kev nyuaj siab.

  3. Kho ntaub so ntswg

    • Txhawb nqa cov txheej txheem thiab kev ua haujlwm zoo hauv cov leeg, ligament, thiab cov leeg nqaij raug mob.

    • Muab kev tiv thaiv neuroprotection hauv nruab nrab paj hlwb raug mob qauv (tus txha caj qaum compression, cerebral ischemia-reperfusion), txo qis neuronal tuag thiab txhim kho lub cev muaj zog / hnov ​​​​qab.

  4. Kev cai ntawm Vascular Tone

    • Ex vivo vascular kev tshawb fawb qhia BPC-157 induces vasorelaxation, nyob ntawm qhov tsis zoo endothelium thiab tsis muaj txoj hauv kev.

Tsiaj & In Vitro Comparative Data

Hom kev sim Qauv / Intervention Dose / Administration Tswj Cov ntsiab lus tseem ceeb Cov ntaub ntawv sib piv
Vasodilation (rat aorta, ex vivo) Phenylephrine-precontracted aortic rings BPC-157 mus txog100 μg / ml Tsis yog BPC-157 Vasorelaxation ~37.6 ± 5.7% Txo rau10.0 ± 5.1% / 12.3 ± 2.3%nrog NOS inhibitor (L-NAME) lossis TSIS MUAJ Scavenger (Hb)
Endothelial Cell Assay (HUVEC) HUVEC culture 1 μg / ml Kev tswj tsis tau kho ↑ TSIS MUAJ ntau lawm (1.35 x 1); ↑ cell migration Migration abolished nrog Hb
Ischemic Limb Model (rat) Mob ntshav qab zib ischemia 10 μg / kg / hnub (ip) Tsis kho Cov ntshav khiav nrawm dua, ↑ angiogenesis Kev Kho Mob> Tswj
Spinal qaum compression (rat) Sacrococcygeal txha caj qaum compression Ib leeg ip txhaj 10 min tom qab raug mob Pab pawg tsis kho Qhov tseem ceeb neurological thiab cov txheej txheem rov qab Pab pawg tswj tseem nyob paraplegic
Hepatotoxicity qauv (CCl₄ / cawv) Chemically induced lub siab raug mob 1 µg lossis 10 ng / kg (ip / qhov ncauj) Tsis kho ↓ AST/ALT, txo necrosis Pab pawg tswj tau pom tias mob siab heev
Kev tshawb fawb toxicity Nas, luav, dev Ntau koob tshuaj / txoj kev Cov tshuaj placebo Tsis muaj toxicity tseem ceeb, tsis pom LD₅₀ Zoo tolerated txawm nyob rau hauv siab koob tshuaj

Kev tshawb fawb txog tib neeg

  • Case series: Intra-articular txhaj ntawm BPC-157 hauv 12 tus neeg mob uas mob hauv caug → 11 qhia txog qhov mob tseem ceeb. Cov kev txwv: tsis muaj pawg tswj hwm, tsis muaj qhov muag tsis pom, cov txiaj ntsig tau tshwm sim.

  • Kev sim tshuaj: Phase I kev nyab xeeb thiab kev tshawb fawb tshuaj pharmacokinetic (NCT02637284) hauv 42 tus neeg tuaj yeem noj qab haus huv tau ua, tab sis cov txiaj ntsig tsis tau tshaj tawm.

Tam sim no,tsis muaj qhov zoo tshaj plaws randomized tswj kev sim (RCTs)muaj nyob rau kom paub meej tias kev kho mob tau zoo thiab kev nyab xeeb.

Kev nyab xeeb & Muaj peev xwm txaus ntshai

  • Angiogenesis: Muaj txiaj ntsig zoo rau kev kho mob, tab sis muaj peev xwm theoretically txhawb cov qog vascularization, ua kom loj hlob lossis metastasis hauv cov neeg mob qog noj ntshav.

  • Dose & Administration: Siv tau rau cov tsiaj hauv cov koob tshuaj tsawg heev (ng–µg/kg), tab sis kev pom zoo tib neeg koob tshuaj thiab txoj kev tseem tsis tau txhais.

  • Kev siv mus ntev: Tsis muaj ntaub ntawv qhia txog kev mob toxicity ntev ntev; feem ntau cov kev tshawb fawb yog luv luv.

  • Kev tswj hwm txoj cai: Tsis pom zoo ua tshuaj hauv ntau lub tebchaws; cais ua ibtxwv tsis publos ntawm WADA (World Anti-Doping Agency).

Kev sib piv kev nkag siab & kev txwv

Kev sib piv Lub zog Kev txwv
Animal vs Human Cov txiaj ntsig zoo sib xws hauv cov tsiaj (cov leeg, paj hlwb, kho lub siab, angiogenesis) Tib neeg cov ntaub ntawv pov thawj tsawg tsawg, tsis muaj kev tswj hwm, thiab tsis muaj kev soj ntsuam mus ntev
koob tshuaj ntau Siv tau ntawm koob tshuaj tsawg heev hauv cov tsiaj (ng–µg / kg; µg / ml hauv vitro) Kev nyab xeeb/zoo tib neeg noj tsis paub
Pib ntawm kev ua Kev tswj xyuas thaum ntxov tom qab raug mob (piv txwv li, 10 feeb tom qab raug mob txha caj qaum) yields zoo rov qab Clinical feasibility ntawm xws li lub sij hawm yog tsis meej
Toxicity Tsis muaj tshuaj tua kab mob lossis muaj kev phom sij loj heev tau pom nyob hauv ntau hom tsiaj Lub sij hawm ntev toxicity, carcinogenicity, thiab kev nyab xeeb ntawm kev yug me nyuam tseem tsis tau kuaj

Xaus

  • BPC-157 qhia tau hais tias muaj zog regenerative thiab tiv thaiv los ntawm cov tsiaj thiab cell qauv: angiogenesis, tiv thaiv kab mob, kho cov ntaub so ntswg, neuroprotection, thiab hepatoprotection.

  • Tib neeg cov pov thawj tsis tshua muaj kev txwv, tsis muaj cov ntaub ntawv kho mob uas muaj zog tuaj.

  • Ntxiv muszoo tsim randomized tswj kev simyuav tsum tsim kom muaj kev ua tau zoo, kev nyab xeeb, kev siv tshuaj kom zoo, thiab kev tswj hwm txoj hauv kev hauv tib neeg.

Post lub sij hawm: Sep-23-2025
Ntaus nkag mus tshawb lossis ESC kom kaw