MOTS-C

Lus piav qhia luv luv:

MOTS-C API yog tsim nyob rau hauv nruj GMP-zoo li tej yam kev mob siv cov khoom theem peptide synthesis (SPPS) technology los xyuas kom meej nws zoo, siab purity thiab siab stability rau kev tshawb fawb thiab kev siv kho mob.
Khoom nta:

Purity ≥ 99% (tau lees paub los ntawm HPLC thiab LC-MS),
Tsawg endotoxin thiab residual kuab tshuaj,
Ua raws li ICH Q7 thiab GMP raws tu qauv,
Muaj peev xwm ua tiav cov khoom loj, los ntawm milligram-theem R & D batch mus rau gram-theem thiab kilogram-theem coj mus muag khoom.

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Product Detail

Khoom cim npe

MOTS-C API

MOTS-C(Mitochondrial Open Reading Ncej ntawm 12S rRNA Type-c) yog 16-amino acidmitochondria-derived peptide (MDP)encoded los ntawm mitochondrial genome. Tsis zoo li cov tsoos nuclear-encoded peptides, MOTS-c keeb kwm los ntawm 12S rRNA cheeb tsam ntawm mitochondrial DNA thiab ua lub luag haujlwm tseem ceeb hauvregulating cellular metabolism, kev nyuaj siab teb, thiab rhiab heev insulin.

Raws li kev kho tshiab peptide,MOTS-c APItau txais txiaj ntsig tseem ceeb hauv cov teb ntawmCov kab mob metabolic, kev laus, kev tawm dag zog lub cev, thiab tshuaj mitochondrial. Lub peptide yog tam sim no nyob rau hauv kev tshawb xyuas preclinical hnyav thiab raug suav tias yog tus neeg sib tw muaj txiaj ntsig rautiam tom ntej peptide khotsom rau kev noj qab haus huv metabolic thiab lub neej ntev.

Mechanism ntawm Action

MOTS-c exerts nws cov teebmeem los ntawmmitochondrial-nuclear cross-hais lus- ib tug mechanism uas mitochondria sib txuas lus nrog lub nucleus kom tswj cellular homeostasis. Lub peptide yog translocated los ntawm mitochondria mus rau lub nucleus nyob rau hauv teb rau metabolic kev nyuaj siab, qhov uas nws ua raws li ib tugmetabolic regulatorlos ntawm kev cuam tshuam gene qhia.

Cov txheej txheem tseem ceeb ntawm cov roj ntsha muaj xws li:

Ua kom AMPK (AMP-activated protein kinase):MOTS-c txhawb nqa AMPK, lub zog nruab nrab ntawm lub zog, txhawb nqaGlucose uptake, fatty acid oxidation, thiab mitochondrial biogenesis.
Kev txhim kho ntawm insulin rhiab heev:MOTS-c nce cov tshuaj insulin hauv cov nqaij thiab cov nqaij adipose, txhim khoglucose homeostasis.
Tiv thaiv oxidative kev nyuaj siab thiab o:Los ntawm modulating cellular redox tshuav nyiaj li cas thiab inflammatory signaling txoj kev.
Kev tswj ntawm mitochondrial muaj nuj nqi thiab biogenesis:Txhawb kev noj qab haus huv mitochondrial, tshwj xeeb tshaj yog nyob rau hauv kev ntxhov siab lossis kev laus.

Kev Tshawb Fawb Txog Kev Kho Mob thiab Kev Siv Tshuaj lom neeg

Cov kev tshawb fawb ua ntej tau pom ntau yam ntawm lub cev thiab kev kho mob ntawm MOTS-c hauv ob qho tib si hauv vitro thiab tsiaj qauv:

1. Cov kab mob metabolic (Obesity, Type 2 Diabetes, Insulin Resistance)

Txhim kho cov ntshav qabzib thiab txo qis cov ntshav qabzib
Txhim khoinsulin rhiab heevtsis nce qib insulin
Txhawb nqapoob phaus thiab rog oxidationnyob rau hauv kev noj cov nas rog rog

2. Anti-Aging thiab Longevity

MOTS-c qib poob qis nrog lub hnub nyoog, thiab ntxiv rau cov nas muaj hnub nyoog tau pomnce lub cev muaj peev xwm, txhim kho mitochondrial muaj nuj nqi, thiabncua hnub nyoog txog kev poob qis.
Txhim kho kev tawm dag zog thiabnqaij endurancelos ntawm kev txhim kho oxidative metabolism.

3. Mitochondrial thiab Cellular Stress Protection

Txhim khocellular ciaj sia nyob rau hauv metabolic los yog oxidative kev nyuaj siabtej yam kev mob.
Nce kev qhia ntawm cov noob txuam nrogkho cellular thiab autophagy.

4. Mob plawv thiab Neuroprotective Potential

Cov kev tshawb fawb ua ntej qhia tias MOTS-c tuaj yeem tiv thaivvascular endothelial hlwbthiab txo cov cim kev nyuaj siab.
Muaj peev xwm neuroprotective zog los ntawmanti-inflammatory thiab antioxidative txoj kevtab tom tshawb nrhiav.

API Manufacturing thiab Quality Attributes

At Gentolex Group, pebMOTS-c APIyog tsim los sivsolid-phase peptide synthesis (SPPS)nyob rau hauv nruj GMP-zoo li tej yam kev mob, kom ntseeg tau zoo, purity, thiab stability rau kev tshawb fawb thiab kev siv kho mob.