Inclisiran sodium

Inclisiran Sodium (API)

Daim ntawv thov tshawb fawb:
Inclisiran sodium API (Active Pharmaceutical Ingredient) yog kawm feem ntau hauv kev cuam tshuam ntawm RNA (RNAi) thiab kev kho mob plawv. Raws li ob-stranded siRNA lub hom phiaj ntawm PCSK9 noob, nws yog siv nyob rau hauv preclinical thiab soj ntsuam kev tshawb fawb los soj ntsuam cov gene-silencing lub tswv yim ntev rau txo LDL-C (tsawg-density lipoprotein cholesterol). Nws kuj tseem ua haujlwm ua qauv sib xyaw rau kev tshawb xyuas siRNA kev xa khoom, kev ruaj ntseg, thiab lub siab-targeted RNA kho.

Muaj nuj nqi:
Inclisiran sodium API ua haujlwm los ntawm kev ntsiag to PCSK9 noob hauv hepatocytes, ua rau txo qis ntawm PCSK9 protein ntau. Qhov no ua rau txhim kho kev rov ua dua tshiab ntawm LDL receptors thiab tshem tawm ntau dua ntawm LDL cov roj cholesterol los ntawm cov ntshav. Nws txoj haujlwm ua tus neeg ua haujlwm ntev-txo cov roj cholesterol txhawb nws txoj kev siv hauv kev kho mob hypercholesterolemia thiab txo cov kev pheej hmoo ntawm cov kab mob plawv. Raws li API, nws tsim cov ntsiab lus tseem ceeb hauv Inclisiran-based tshuaj formulations.