AEEA-UA

AEEA-AEEA (Aminoethoxyethoxyacetate dimer)

Daim ntawv thov tshawb fawb:
AEEA-AEEA yog hydrophilic, hloov tau yooj yim spacer feem ntau siv nyob rau hauv peptide thiab tshuaj conjugation kev tshawb fawb. Nws muaj ob chav ethylene glycol-based units, ua rau nws muaj txiaj ntsig zoo rau kev kawm txog qhov cuam tshuam ntawm qhov txuas txuas ntev thiab yoog raws ntawm kev sib cuam tshuam ntawm molecular, solubility, thiab lom lom. Cov kws tshawb fawb feem ntau siv AEEA cov chav ntsuas los ntsuas seb cov spacers cuam tshuam li cas ntawm cov tshuaj tiv thaiv kab mob sib txuas (ADCs), peptide-drug conjugates, thiab lwm yam bioconjugates.

Muaj nuj nqi:
AEEA-AEEA ua haujlwm raws li biocompatible linker uas txhim kho solubility, txo steric hindrance, thiab txhim kho molecular yooj. Nws pab cais cov haujlwm ua haujlwm nyob rau hauv ib lub molecule, xws li lub hom phiaj ligands thiab payloads, tso cai rau kom muaj txiaj ntsig zoo thiab kev ua haujlwm. Nws tsis yog-immunogenic thiab hydrophilic xwm kuj pab txhawb kev txhim kho pharmacokinetic profiles hauv kev siv kho mob.