20mg Retatrutide Poob Poob Peptide Lyophilized Powder Reta Vials Txhaj 99% Retatrutide

Product Description
Retatrutide yog ib qho tshiab triple agonist peptide tsom rau glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), thiab glucagon-zoo li peptide-1 receptor (GLP-1R). Retatrutide ua rau tib neeg GCGR, GIPR, thiab GLP-1R nrog EC50 qhov tseem ceeb ntawm 5.79, 0.0643, thiab 0.775 nM, raws li, thiab nas GCGR, GIPR, thiab GLP-1R nrog EC50 qhov tseem ceeb ntawm 2.32, 0.194, thiab nas. Nws ua hauj lwm raws li ib tug tseem ceeb kev tshawb fawb cuab yeej nyob rau hauv txoj kev tshawb no ntawm rog rog thiab metabolic mob.

Retatrutide ua haujlwm tau zoo ua rau GLP-1R qhia txoj hauv kev thiab txhawb nqa cov piam thaj-dependent insulin secretion los ntawm kev ua haujlwm ntawm GIP thiab GLP-1 receptors. Cov peptide hluavtaws no nthuav tawm cov khoom muaj zog hypoglycemic thiab tau tsim los ua cov tshuaj tiv thaiv kab mob ntshav qab zib hom 2 (T2D). Nws txhawb nqa cov tshuaj insulin tso tawm thiab txo qis glucagon secretion hauv cov piam thaj-dependant.

Tsis tas li ntawd, Retatrutide tau pom tias yuav ncua lub plab zom mov, txo qis kev yoo mov thiab qib qabzib tom qab, txo cov zaub mov noj, thiab ua rau lub cev hnyav hnyav rau cov tib neeg uas muaj T2D.

Kev ua lom lom
Retatrutide (LY3437943) yog ib qho lipid-conjugated peptide uas ua haujlwm ua lub zog agonist ntawm tib neeg GCGR, GIPR, thiab GLP-1R. Piv nrog rau tib neeg glucagon thiab GLP-1, Retatrutide nthuav tawm qis zog ntawm GCGR thiab GLP-1R (0.3 × thiab 0.4 ×, raws li), tab sis qhia tau tias muaj zog (8.9 ×) ntawm GIPR piv nrog cov piam thaj-dependent insulinotropic polypeptide (GIP).

Mechanism ntawm Action
Hauv kev tshawb fawb txog cov nas mob ntshav qab zib nrog nephropathy, Retatrutide kev tswj hwm txo qis albuminuria thiab txhim kho glomerular pom tus nqi. Qhov kev tiv thaiv no yog ntaus nqi los ntawm kev ua kom muaj GLP-1R / GR-raws txoj kev taw qhia, uas kho cov tshuaj tiv thaiv thiab tiv thaiv apoptotic hauv lub raum cov ntaub so ntswg.

Retatrutide kuj ncaj qha hloov kho glomerular permeability, txhim kho cov zis muaj peev xwm. Cov kev tshawb pom ua ntej qhia tias, piv rau cov kev kho mob raum tsis zoo xws li ACE inhibitors thiab ARBs, Retatrutide ua rau txo qis hauv albuminuria tom qab tsuas yog plaub lub lis piam ntawm kev kho mob. Tsis tas li ntawd, nws tau pom tias muaj txiaj ntsig zoo dua hauv kev txo cov ntshav siab ntau dua li ACE inhibitors lossis ARBs, tsis muaj qhov cuam tshuam loj heev.

Cov teebmeem
Cov kev mob tshwm sim feem ntau ntawm Retatrutide yog plab hnyuv, nrog rau xeev siab, raws plab, ntuav, thiab cem quav. Cov tsos mob no feem ntau me me mus rau nruab nrab thiab yuav daws tau nrog kev txo koob tshuaj. Kwv yees li 7% ntawm cov neeg mob kuj tau tshaj tawm cov kev xav ntawm daim tawv nqaij tingling. Kev nce hauv lub plawv dhia tau pom ntawm 24 lub lis piam hauv cov pab pawg ntau dua, uas tom qab ntawd rov qab mus rau theem pib.